GVHD. A reaction of donated bone marrow or peripheral stem cells against a person's tissue.
GVHD. A reaction of donated stem cells against the patient's tissue.
disease where immunocompetent lymphocytes in grafted bone marrow attempt to reject the host tissues; treated by immunosuppressive therapy.
A condition that occurs following bone marrow transplant in which the donor’s immune cells, in the transplanted marrow, make antibodies against the host’s tissues.
Complication of allogeneic transplants resulting from donor immune cells recognizing the recipient's cells as foreign and mounting an attack against them.
A reaction where transplanted or transfused cells attack the recipient's own cells.
A condition that occurs after tissue transplantation in which the donor-derived T cells attack the host's tissues.
An immunological reaction of donor bone marrow or stem cells against the transplanted patient.
A condition where transplanted stem cells may react against the patient's body. Symptoms may range from a minor skin rash to more serious problems resulting in lifethreatening conditions.
A complication of bone marrow transplants in which T cells in the donor bone marrow graft go on the offensive and attack the host's tissues. Graft-versus-host disease (GVHD) is seen most often in cases where the blood marrow donor is unrelated to the patient or when the donor is related to the patient but not a perfect match. There are two forms of GVHD: an early form called acute GVHD that occurs soon after the transplant when the white cells are on the rise and a late form called chronic GVHD. See the entire definition of Graft-versus-host disease
GVHD A reaction of donated bone marrow against a patient's own tissue.
a condition in which transplanted immune tissue (e.g., bone marrow cells) attack the tissues of the new host's body.
A condition that can occur following an allogenic BMT in which some of the donor's bone marrow cells attack the patient's tissues and organs.
when the donor's immune system acts against the recipient's tissue, after transplantation.
After bone marrow transplantation, immune cells in the donated (grafted) material may identify the patient's (host) tissue as foreign and try to destroy them. This can be a serious problem, and drugs are available to combat it. However, in some cases, a GVH reaction actually helps to control the cancer.
The consequence of an immune reaction of transplanted allogeneic lymphocytes (usually contained in a bone marrow graft) against alloantigens of the recipient (host).
A life-threatening reaction in which transplanted immunocompetent cells attack the tissues of the recipient.
A complication after BMT in which the transplanted stem cells cause the recipient’s new immune system to attack his or her own body cells and tissue. Its severity will depend on how well the antigens of the recipient and donor match. Symptoms may include skin rash, blisters, diarrhea and jaundice.
A condition that may develop after allogeneic bone marrow transplantation; the transplanted marrow (graft) attacks the patient's (host's) organs.
A condition that results when a donated organ reacts against the recipient's own tissue; symptoms include skin rash, fever, diarrhea, liver dysfunction, abdominal pain, and loss of appetite.
A major complication of allogeneic bone marrow transplantation. In this condition, mature donor T cells from the transplanted bone marrow recognize the recipient’s cells as non-self, leading to a severe inflammatory reaction characterized by rashes, diarrhea, and liver disease (Janeway et al., 2005).
A disease caused by the infusion or transplantation of immune cells from one individual into another.
Graft-versus-host disease (GVHD) is a common complication of allogeneic bone marrow transplantation in which functional immune cells in the transplanted marrow recognize the recipient as "foreign" and mount an immunologic attack. After bone marrow transplantation, T cells present in the graft, either as contaminants or intentionally introduced into the host, attack the tissues of the transplant recipient after perceiving host tissues as antigenically foreign. The T cells produce an excess of cytokines, and the fierce interplay of these cytokines, including TNF alpha and interleukin-1 (IL-1), was first http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8442093&query_hl=2&itool=pubmed_DocSum classified as a cytokine storm by Ferrara and co-workers in 1993.