a common, and serious, complication of bone marrow transplantation. Some of the donor's immune cells reject the patient's own cells as foreign. The skin, liver and gut may be affected.
A potential complication of transplants associated with the use of blood or tissue from a different person ( allogeneic). In GVHD, the transplanted cells reject the recipient's tissue as foreign and attack the tissue. GVHD in stem cell transplants appears to be less severe with umbilical cord blood, which appears to be more tolerant of the new body's environment. To reduce the risk of GVHD or tissue rejection, HLA testing is required. Order HLA testing online here.
A possibly life-threatening condition where the transplanted donor marrow or blood stem cells attack the patientâ€(tm)s body.
A transplantation syndrome wherein mature T lymphocytes from an allogeneic donor undergo an immune response against tissues and organs of the host. These immune responses can vary in degree, from mild skin, gut, and liver damage to lethal disease. The usual circumstance is an allogeneic bone marrow (BM) or mobilized peripheral blood (MPB) transplant from healthy donors to hosts who have received substantial pre-transplant conditioning, which prevents host immune rejection of donor cells. In that circumstance, donor mature T lymphocytes are present as contaminants of HSC and blood progenitors. Pure allogeneic HSC transplants do not cause graft versus host disease.
A side effect of a bone marrow or stem cell transplant that occurs when new bone marrow or stem cells (the graft) reject or attack the patient's body (the host).
A common complication of allogeneic blood and marrow transplantation where there is a reaction of the donated hematopoietic progenitor cells against the recipient's own tissue.
A condition where the transplanted donor marrow or blood stem cells attack the patient's body. GVHD can be mild or serious and is sometimes life threatening.
a condition where transplanted cells from the donor attack the cells of the host's body. In the first 100 days, the tissues most likely to be attacked are the skin, GI tract , and the liver.
