These are proteins on the surface of the bodies' cells. They help the immune system recognize our own cells as “self†as opposed to “foreign†-- based on the HLA proteins present. We try to find the best HLA match for a patient who needs an allogeneic transplant.
A series of antigens found on white blood cells and most other cells of the body that are used to determine tissue type. Your HLA allows your immune system to recognize self from non-self. When these proteins are the same for both donor and recipient, an allogeneic stem cell transplant is much more likely to be successful. In stem cell transplantation, the HLA antigens routinely typed for are HLA-A, B, and DR.
A protein that is found on cells that must be matched between a donor and a transplant recipient before a transplant can take place. PLASTICITY: The ability to which a stem cell can be manipulated into becoming another type of cell.
Genetic "fingerprint" on human white cells (and platelets), composed of proteins that play a critical role in activating the body's immune system to respond to foreign organisms. Inherited from both parents. Determined by HLA-typing, which can be performed with antisera and with DNA techniques
A set of six antigens used to match a blood or bone marrow donor to a recipient. These antigens appear on white blood cells as well as cells of almost all other tissues and are analogous to red blood cell antigens (type A, B, O, etc.). By typing for HLA antigens, donors and recipients of white blood cells, platelets, and organs can be matched to ensure good performance and survival of transfused and transplanted cells. A perfect HLA match occurs only between identical twins.
Proteins on the surface of cells that are important in transplantation and transfusion. For BMTs, the HLAs on white cells of the patient and potential donor are compared. A perfect HLA match occurs only between identical twins.
MHC molecules expressed on the surface of human cells human MHC were first identified as alloantigens on the surface of white blood cells leukocytes) that bind serum antibodies from individuals previously exposed to other individuals' cells. (e.g., mothers or transfusion recipients) (1).
Genetic markers found on all cells of the body that determine white blood cell types. HLA tissue types are used to match donated organs or bone marrow with transplant recipients. Jump to Top
(e.g., HLA-DR4 and HLA-DR1): Tissue-specific 'marker' proteins (HLA proteins) that are found on the surface of some cells, such as leukocytes (white blood cells). These proteins correspond to the HLA genes that are located on chromosome 6 in humans.
Markers that identify cells as "self" and prevent the immune system from attacking them.
The system for determining and identifying a person's antigen makeup (before kidney and pancreas transplants).
antigens, tolerated by the body, that correspond to genes that govern immune responses. Also known as major histocompatibility complex.
A set of genes specific to the immune system that ideally should match when someone has an organ transplant. Certain HLA types can predispose individuals to develop particular diseases, especially autoimmune diseases. For example, HLA class II gene DRB1*0402 is recognized in people with Pemphigus Vulgaris.
Protein in markers of self used in histocompatibility testing. Some HLA types also correlate with certain autoimmune diseases.
Proteins on white blood cells that make each person's tissue unique. The HLA A, B, C and DR proteins are important in matching patients and donors for a marrow or blood stem cell transplant.
