Any substance with an ODP greater than 0 that can deplete the stratospheric ozone layer. Most of ODS are controlled under the Montreal Protocol and its amendments and they include CFCs, HCFCs, halons and methyl bromide.

Chemicals such as CFCs which react with the ozone in the earth's protective ozone layer in the upper atmosphere.

A compound that contributes to stratospheric ozone depletion. Ozone-depleting substances (ODS) include Chloroflurocarbons (CFCs), Hydrochloroflurocarbons (HCFCs) halons, methyl bromide, carbon tetrachloride, and methyl chloroform. ODS are generally very stable in the troposphere and only degrade under intense ultraviolet light in the stratosphere. When they break down, they release chlorine or bromine atoms, which then deplete ozone.