Interstate 495 (abbreviated I-495) runs 71.02 miles (114.34 km) entirely within New York state, from the Queens Midtown Tunnel in New York City to Riverhead, New York, through the boroughs of Manhattan and Queens, and Nassau and Suffolk counties, ending just before the 'fish-tail' separation of the North and South Forks of eastern Long Island. I-495 is better known by New Yorkers as the Long Island Expressway, which is often abbreviated as LIE. Within Queens, it is often subdivided by name into two sections: the Queens-Midtown Expressway from the Queens-Midtown Tunnel portal/toll plaza to the intersection over Queens Boulevard, and the Horace Harding Expressway from said intersection to the Nassau County line.

Interstate 495 (abbreviated I-495) is the designation of an Interstate highway ½ beltway in Massachusetts. It was the longest interstate highway of its kind – measuring in at 120.74 miles (194.40 kilometers) – until its title was taken by Interstate 476 in 1996.

Interstate 495 (abbreviated I-495) is a freeway-class interstate highway which circles Washington, D.C. and its inner suburbs in Maryland and Virginia. I-495 is widely known as the Capital Beltway or simply as the Beltway, especially when the context of Washington, D.C., is clear. It is the basis of the phrase "inside the Beltway", used when referring to issues dealing with American government and politics.