a variable proportion of an administered chemotherapeutic drug delivered into the circulation and available for potential therapeutic effect on the tumor.
(Biodisponibilité) The degree to which a substance is available to be absorbed and metabolized by an exposed living organism.
Proportion of a given dose of drug that actually reaches the blood stream.
The extent to which a substance can readily be absorbed by an organism or is ready to interact in an organism's metabolism.
The percentage of drug that is detected in the systemic circulation after its administration. Losses can be attributed to an inherent lack of absorption/passage into the systemic circulation and/or to metabolic clearance. Detection of drug can be accomplished pharmacodynamically (quantification of a biological response to the drug) or pharmacokinetically (quantification of actual drug concentration). Oral bioavailability is associated with orally administered drugs.
(BY-o-uh-vale-ah-BILL-ih-tee) The amount of drug absorbed into the body
The ability of a drug or other chemical to be taken up by the body and made available in the tissue where it is needed.
Extent to which a pesticide residue can be taken up into an organism from its food and environment, and the rate at which this occurs. (Duffus, 1993)
extent of availability of drugs in the body
Indicates measurement of the rate and amount of drug that reaches the general circulation from an administered dosage form.
The degree to which the active form of a drug reaches the target tissues of the body. For example, a drug may have low bioavailability when given orally because it is poorly absorbed in the digestive tract.
how much of the drug is absorbed into the bloodstream
The rate and extent to which a nutrient is absorbed and is available for use by the body.
the extent to which a metabolite or drug can be utilized by its site of action. Ie/ some forms of calcium have higher bioavailability than others.
The extent to which the body can utilise a particular nutrient.
Bioavailability is the degree to which an agent, such as a drug or nutrient, becomes available at the site of activity in the body.
A chemical is bioavailable when it is in a form that can be taken up or absorbed by plants and animals.
Measure of the true rate and the total amount of drug that reaches the target tissue after administration.
The extent to which a chemical is absorbed and distributed in the blood in an unchanged form following administration to a living organism
biological availability of the nutrients in a food. When a food contains nutrients that cannot be digested (released) and absorbed, the bioavailability of the nutrients is low. Even though they can be measured chemically, they cannot be used biologically.
The extent to which living organisms can extract toxic chemicals from sediments or other materials. If a substance is not bioavailable, it cannot cause toxic effects.
The degree and rate at which a substance is absorbed into the body.
The rate and extent to which an AGENT can be absorbed by an organism and is available for metabolism or interaction with biologically significant receptors. BIOAVAILABILITY involves both release from a MEDIUM (if present) and absorption by an organism.
The percentage of drug delivered to the intended location in the body, typically the percentage absorbed into the blood from oral, pulmonary, transdermal, nasal, or injectable routes. How metabolically available a drug or other chemical becomes to the target tissue after being introduced into the body.
the rate and extent to which a drug enters the general circulation and can be used by the body
The extent to which an ingested nutrient is absorbed, taken up by the body's tissues and utilised for its specific functions.
A measure of the amount of drug which is absorbed into the body and is available to exert its biological action.
The ability of an ingested nutrient to cross from the digestive tract into the bloodstream and then from the bloodstream into the cells in which it will be utilized.
Extent to which (sometimes the rate at which) the active drug ingredient enters systemic circulation, thereby gaining access to its site of action.
the degree to which a drug, medication or other substances (for example, iron) becomes available for use by the body after administration.
The degree to which a drug or other substance becomes available to the target body tissue after administration.
The extent to which a substance (e.g., a drug) is absorbed and circulated in the body.
the degree a drug or nutrient is available to the body. Bioavailability is influenced by how much the substance is absorbed and circulated.
The amount of a nutrient that enters the bloodstrean and thus reaches the tissues and organs of the body.
The proportion of a drug or nutrient which enters the circulation when introduced to the body and which is therefore available to have an active effect.
A measurement term for the speed of and absorption rate of a substance into the bloodstream.
the amount of a drug in a capsule or tablet that is actually metabolized.
The availability of a given amount of a substance (vitamin or mineral) that can be absorbed from the gastrointestinal tract.
The rate and extent to which the active ingredient or active moiety is absorbed from a drug product and becomes available at the site of action.
This is the simplicity at which nutrients can be absorbed in the body.
The extent to which an oral medication is absorbed in the digestive tract and reaches the bloodstream.
The extent to which a pollutant is available for uptake and accumulation by living organisms.
The extent to which a compound is obtainable for biological use by organisms.
The simplicity in which nutrients can be absorbed.
the degree to which a drug or other substance is absorbed and circulated in the body; the physiological availability of a drug, as opposed to its chemical potency.
The ease at which nutrients can be absorbed.
The ability of nutrients to be digested, assimilated and used by the body, rather than passing through undigested.
The rate and extent to which a drug or dietary supplement is absorbed into general circulation, thereby permitting access to the site of action. Measured by the concentration in body fluids, usually blood, or by the magnitude of the pharmacological response. Expressed as a fraction of an administered dose.
Refers to the rate and extent that nutrients are absorbed and utilized by the body.
A term for a substance's speed of, and extent of, absorption into the circulating bloodstream so that it can be effectively administered by the body to where it is needed. This is expressed in a fraction of a given dose.
Extent to which a substance to which the body is exposed (by ingestion, inhalation, injection, or skin contact) reaches the systemic circulation, and the rate at which this occurs. SN biological availability, physiological availability. Pharmacokinetic term relating systemic exposure from extravascular exposure (ev) to that following intravenous exposure (iv) by the equation: AUCev*Div / AUCiv*Dev where is the bioavailability, AUCev and AUCiv are the areas under the plasma concentration time curve following extravascular and intravenous administration and Dev and Div are the administered extravascular and intravenous doses.
The extent to which a compound is available for intake by organisms. Bioavailable compounds have the potential to cause biological effects, such as increased mortality.
A measure of how much of an administered drug is absorbed into the bloodstream, actually reaching the intended site of action in the body. For example, medicine is absorbed from the GI tract, travels through the bloodstream and reaches the organ tissues, where it works to fight infection, prevent rejection, etc.
Chemical property of a drug describing its absorption through the gastrointestinal tract when taken orally.
when food is found in a form readily absorbable by the intestines
how completely a particular drug is absorbed by the system.
A measure of how much drug makes it into the bloodstream, compared to how much we swallow.
The degree to which a substance becomes available to the target tissue after administration or exposure.
(bi-oh-ah-vale- ah-BILL-i-tee) the amount of drug that is available to the target tissue after administration; this may not be 100% due to degradation or alteration before reaching the target tissue
The rate and extent to which a substance is absorbed and circulated in the body.
In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via other routes (such as by mouth), its bioavailability decreases (due to incomplete absorption and first-pass metabolism).
