The Breast Cancer 1 and 2 genes, which are the two major genes responsible for inherited predisposition to breast cancer (and, especially for BRCA1, to ovarian cancer as well). These genes are responsible for 80% to 90% of hereditary breast cancer. BRCA1 was discovered in 1994 and BRCA2 was discovered in 1995.
First breast cancer genes to be identified. Mutated forms of these genes are believed to be responsible for about one-half the cases of inherited breast cancer, especially those that occur in younger women, and also to increase a woman's risk for ovarian cancer. Both are tumor-suppressor genes.
These are two genes that are known to play a part in breast cancer risk. Women who inherit a defective BRCA1 or BRCA2 gene from either or both of their parents may have a higher chance of developing breast cancer than women who have not inherited one of these defective genes. Women who have a high rate of breast cancer in their families can have a test done that can tell them if they have a defective BRCA1 or BRCA2 gene.
Two genes that are important in breast cancer. Certain changes in either BRCA1 or BRCA2 result in an increased risk of developing breast, ovarian, or certain other cancers. BRCA1 was identified in 1994, and BRCA2 was discovered in 1996.
The principal genes that indicate an inherited susceptibility to breast and ovarian cancers; accounting for 80-90% of all inherited cases of breast and the majority of inherited ovarian cancers.
two genes which normally help to restrain cell growth, but which can contain certain genetic mutations associated with the development of breast and ovarian cancer. Note, however, that inherited BRCA1 and BRCA2 mutations are thought to account for less than 10% of all breast and ovarian cancers. Recent evidence suggests that somatic cell genetic mutations (i.e., non-inherited genetic mutations) in these two genes may also play a role in the development of cancer.
The names of two genes that seem to be linked in some women to the development of breast cancer. BRCA stands for breast cancer. BRCA1 was the first identified gene discovered to be related to breast cancer; BRCA2 was the second.
The principal genes that indicate an inherited susceptibility to breast and ovarian cancers. These genes account for approximately 80% to 90% of all hereditary cases of breast cancer and the majority of hereditary ovarian cancer.
