Breast cancer gene 2 has been identified recently on chromosome 13. See also familial breast cancer.

Gene that increases the risk of getting breast and ovarian cancer in women and breast and prostate cancer in men. Out of every 100 women carrying this gene, between 80 and 85 will develop breast cancer at some point in life (80-85% lifetime risk). Ovarian cancer lifetime risk is about 27%. Male carriers have a breast cancer risk of 5% and a prostate cancer risk of 6 - 14%. However, most cancers (95 out of 100 breast cancers) are sporadic, which means there is no inherited gene involved. If you have cancer and there are several breast and/or ovarian cancers in your family, it may be possible for you or your relatives to be tested for this gene.

Genes that normally help to restrain cell growth, but in their altered or mutated form predispose an individual to breast, ovarian, and prostate cancer. Mutations of BRCA1 and BRCA2 are sometimes passed down genetically through families or ethnic groups.

A gene which, when mutated,increases the risk of developing breast and ovarian cancers.

Two genes that are associated with an increased risk of breast cancer when they have mutations. Every human being has these two genes, which make proteins that are responsible for preventing cancer from forming. When mutations happen in these genes, the protective proteins do not work as well and the individual is then at increased risk of developing cancer. A mutation in the BRCA1/2 genes can be inherited or it can be acquired during our lifetime.

A tumor-suppressing gene. Even if one copy of it is damaged, cancer can develop.

Two mutant genes that are responsible for approximately 50 percent of all inherited forms of breast cancer. Normally these genes are tumor suppressors, which limit the growth of tumors. When mutated, these genes fail to do their job correctly, allowing cancers to grow.

a gene, which, when damaged or mutated, places a woman at a much higher risk for developing breast cancer and/or ovarian cancer than the general population.

gene located on chromosome 13 that scientist believe may account for 30-40 % of all inherited breast cancer.

Breast cancer gene 2. Another gene implicated in familial breast cancer. In a woman with a BRCA2 mutation, the estimated lifetime risk of developing breast cancer is 55%. BRCA2 and BRCA1 together account for about 80% of the breast cancer that occurs in women with strong family histories of the disease.

A gene on chromosome 13 that codes for a protein that normally restrains cell growth.

A gene located on chromosome 13 that normally produces a protein that normally helps to restrain cell growth.

A gene on chromosome 13 that normally helps to suppress cell growth. A person who inherits an altered version of the BRCA2 gene has a higher risk of getting breast, ovarian, or prostate cancer.

A gene that normally acts to restrain the growth of cells in the breast and ovary but which, when mutated, may predispose to breast cancer and to ovarian cancer . BRCA2 mutations have also been discovered to be responsible for a significant fraction of early-onset prostate cancer . The first breast cancer genes identified were BRCA1 and BRCA2. Mutations of BRCA1 and BRCA2 account for about half of all cases of inherited breast cancer. These tumors tend to occur in young women. BRCA1 and BRCA2 are usually not involved in breast cancer that is not hereditary. See the entire definition of BRCA2

a gene which, when damaged or mutated, puts the carrier at a much higher risk for developing breast cancer and/or ovarian cancer than the general population. In a woman with a BRCA2 mutation, the estimated lifetime risk of developing breast cancer is 50% - 60%. BRCA2 and BRCA1 together account for about 80% of the breast cancer that occurs in women with strong family histories of the disease. BRCA2 is also thought to raise the risk for breast cancer in men. A genetic test for BRCA2 is available but is only recommended for those with strong family histories of breast or ovarian cancer. The ACS recommends that anyone tested also receive genetic counseling.

BRCA2 is a human gene that is involved in the repair of chromosomal damage and belongs to a class of genes known as tumor suppressor genes. Tumor suppressor genes regulate the cycle of cell division by keeping cells from growing and dividing too rapidly or in an uncontrolled way.