A blending of functional genomics and molecular toxicology working to establish correlations between responses to toxicants and changes in the genetic profiles of an organism exposed to environmental stressors.
The collection, interpretation, and storage of information about gene and protein activity in order to identify toxic substances in the environment, and to help treat people at the greatest risk of diseases caused by environmental pollutants or toxicants.
The genome-wide study of the effects of toxic substances on gene and protein expression.
A fusion of genomics and toxicology disciplines intended to identify, classify and manage the latent (inherent susceptibility), incipient and overt adverse (toxic) effects on genome structure and expression levels (RNA, protein, cell/tissue/organ type) as a consequence of an organism's exposure to environmental substances (contaminants such as chemicals, drugs and micro/multicellular organisms and/or components) and stressors (for example, quality of air, climate, soil, solar radiation and water).
The study of how genomes respond to environmental stressors or toxicants.
a new scientific subdiscipline that combines the emerging technologies of genomics and bioinformatics to identify and characterize mechanisms of action of known and suspected toxicants. Currently, the premier toxicogenomic tools are the DNA microarray and the DNA chip, which are used for the simultaneous monitoring of expression levels of hundreds to thousands of genes.
Toxicogenomics is a form of analysis by which the activity of a particular toxin or chemical substance on living tissue can be identified based upon a profiling of its known effects on genetic material. Once viable, the technique should serve for toxicology and toxin-determination a role analogous to DNA-testing in the forensic identification of individuals.
