A midbrain region involved in the control of motor behavior. Loss of dopamine-releasing neurons of the substantia nigra underlies the movement disorder called Parkinson's disease.
A part of the midbrain that contains dopamine-producing neurons and is involved in the regulation of voluntary motor movement.
A group of nerve cells at the base of the midbrain that receives input from a number of nerve cells. Some scientists consider the substantia nigra to be a part of the basal ganglia.
is found in the midbrain. There are two parts to it: the pars compacta provides a dopaminergic input to the neostriatum, while the pars reticulata component provides a GABAergic input to the thalamus and brainstem
a layer of deeply pigmented gray matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease
A part of the brain involved in initiating movement. It is situated near the center of the brain and contains a clump of dark cells that manufacture dopamine.
Part of the basal ganglia in the brain. It co-ordinates movement and contains the cells that produce dopamine.
sub STAN shuh NIGH gruh] One of the movement control centers in the brain where loss of dopamine-producing cells trigger Parkinson's disease symptoms.
The substantia nigra has been described as the 'gear box' of the brain. When this is not working properly it leads to a movement disorder.
A group of nerve cell bodies in the mid-brain that contain dopamine. It is this part of the brain that degenerates in Parkinson's disease. The levels of the neurotransmitter dopamine are unusually low in Parkinson's patients. Replacement of dopamine is one strategy to relieve symptoms.
A small cluster of black-pigmented nerve cells in the brain that produce dopamine. Messages from the substantia nigra are transmitted to the striatum.
A layer of large, pigmented neurons found in the midbrain. They control motor skills and produce dopamine.
a layer of deeply pigmented gray matter situated in the midbrain and containing dopamine secreting nerve cell bodies [deficient in Parkinson's disease].
Black pigmented area of the midbrain where cells manufacture the neurotransmitter dopamine.
A large neuromelanin containing nuclear area ventral to the tegmentum extending throughout the rostrocaudal extent of the midbrain and into the caudal part of the ventral diencephalon. Consists of a ventral pars reticulata and a dorsal part called the pars compacta. Neurons in the pars compacta use dopamine as a neurotransmitter and project primarily to the neostriatum.
a small area of the brain containing a cluster of black-pigmented nerve cells that produce dopamine, which is then transmitted to the striatum.
A dark band of gray matter deep within the brain where cells manufacture the neurotransmitter dopamine for movement control. Damage to cells in this region may lead to a neurologic movement disorder such as Parkinson's disease.
area of the brain where cells produce dopamine
a group of dark colored cell bodies in the midbrain which produce dopamine; the substantia nigra is part of the extrapyramidal system
an area of the midbrain containing a cluster of black-pigmented nerve cells that produce dopamine.
Dopamine-producing nerve cells located in the brain stem that control voluntary movement
A tiny, black pigmented area of the brain that produces dopamine and deteriorates in PD
a layer of deeply pigmented gray matter situated in the midbrain and containing the cell bodies of a tract of dopamine-producing nerve cells.
A discrete brain area that is part of the nigrostriatal system, interacts with the limbic system, has a large number of dopamine-containing cells, and is involved in learning to automatically execute complex movements triggered by a voluntary command; degenerative impairments in this area cause motor disturbances that occur in Parkinson's disease.
An area of the midbrain. Lesions can result in akinesia. Due to tremor at rest of Parkinson's disease
movement-control center in the brain where loss of dopamine-producing nerve cells triggers the symptoms of Parkinson's disease; substantia nigra means "black substance," so called because the cells in this area are dark.
The part of the brain, dark in color, that produces dopamine.
Literally means "black substance." A part of the basal ganglia, located in the midbrain, that is rich in dopamine-producing nerve cells and the black pigment neuromelanin (hence its name). In Parkinson's the loss of nerve cells from this region leads to a dopamine deficit and subsequently to Parkinson's symptoms.
The substantia nigra, (Latin for "black substance", Soemering) or locus niger is a heterogeneous portion of the midbrain, separating the pes (foot) from the tegmentum (covering), and a major element of the basal ganglia system. It consists of two strongly contrasted ensembles, the pars compacta and adjacent dopaminergic groups, and another ensemble made up of the pars reticulata and the pars lateralis. The last two, along with the pallidal nuclei, are elements of the core of the basal ganglia.