Definitions for "Progressive disease"
Cancer that is growing, spreading, or getting worse.
Myeloma disease that continues to progress despite therapy (ie, a greater than 25% increase in M protein, new bony lesions, or a new plasmacytoma). Relapsed and/or refractory disease can be considered to be progressive disease.
Progressive disease is defined in clinical trials as tumor growth of more than 20 percent since treatment began. Tumor growth means that the tumor is getting bigger, but it may also mean that the tumor is spreading. Progression generally indicates that treatment has stopped working.
Cancer that is increasing in scope or severity.