Major Histocompatabilty Complex. A group of genes, called a “complex” because they lie close together on a single chromosome, which governs immune system function. MHC genes are highly polymorphic.
A genetic system of man that determines the antennae (cell surface molecules) on lymphocytes that are responsible for antigen presentation to T lymphocytes in the elicitation and the expression (the beginnings) of an immune response. This genetic system is responsible for rapid rejection of grafts between individuals that are not appropriately matched. This system is responsible for the rejection of pregnancies and embryos in individuals that are too closely matched at DR and DQ. In this latter context "compatibility breeds contempt", and an allergy to the placenta of the baby develops.
Major histocompatibiliy complex. There are two classes of MHC molecules. MHC class I molecules are found on the surface of most cells and present proteins that are generated in the cytosol to T lymphocytes. MHC class II molecules are expressed only at the surface of activated antigen-presenting cells, and they present peptides that have been degradated in cellular vesicles to T cells (3).
a genetic region that encodes the MHC proteins, known by the acronym HLA (human leucocyte antigen) in humans.
Major histocompatability complex. A specific cluster of genes that encode proteins involved in immune system reactions. See Human leucocyte antigen.
major histocompatibility complex. In mammals, a cluster of closely linked loci (approx. 1500-2500 kb) involved in a variety of immunological processes. The gene products of MHC are cell membrane glycoproteins which demonstrate a high degree of polymorphism.
Major histocompatibility complex. Group of genes that code for proteins involved in transplantation rejection and the regulation of the immune response. In man they are located on chromosome 6.
major histocompatibility complex. A large set of cell surface antigens encoded by a family of genes. Foreign MHC markers trigger T-cell responses that may lead to the rejection of transplanted tissues and organs. Malpighian tubule(mal- pig-ee-un) A unique excretory organ of insects that empties into the digestive tract, removes nitrogenous wastes from the blood, and functions in osmoregulation.
Abbreviation of major histocompatibility complex. microbe[Gk. mikros, small + bios, life] A microscopic organism.
Major histocompatibility complex. The genetic loci that encode the histocompatibility antigens, cell-surface proteins that bind peptide fragments of foreign proteins, present them to T-lymphocytes, and induce an immune response.
major histocompatibility complex. a group of genes. They produce proteins which help to control signalling between antigen presenting cells and lymphocytes.
major histocompatibility complex. Proteins recognised by T-cells in the immune response. Class I MHC molecules are involved in T-cell interactions and graft or organ transplant rejections.
Major Histocompatibility Complex. two classes of molecules on cell surfaces. MHC class I molecules exist on all cells and hold and present foreign ANTIGENS to CD8 CYTOTOXIC T LYMPHOCYTES if the cell is infected by a VIRUS or other MICROBE. MHC class II molecules are found on the IMMUNE SYSTEM's ANTIGEN PRESENTING CELLS and display antigen to activate CD4 CELLS.
see MAJOR HISTOCOMPATIBILITY COMPLEX.
Major histocompatibility complex. proteins whose major function is to present to the T cells peptides resulting from the fragmentation, or processing, of antigenic proteins.
the gene cluster that controls certain aspects of the immune response. Among the products of these genes are the histocompatibility antigens, such as HLA class I antigens, which are present on every cell with a nucleus and serve as markers to distinguish self from non-self. (See also HLA.)
MAJOR HISTOCOMPATIBILITY COMPLEX. Two classes of molecules on cell surfaces. MHC class I molecules exist on all cells, and hold and present foreign antigens to CD8 cytotoxic T lymphocytes if the cell is infected by a virus or other microbe. MHC class II molecules are the billboards of the immune system. Peptides derived from foreign proteins are inserted into MHC's binding groove and displayed on the surface of antigen-presenting cells. These peptides are then recognized by T lymphocytes so that the immune system is alerted to the presence of foreign material. See Histocompatibility Testing.
Major Histocompatibility Complex. molecules that are found on cell surfaces and display antigen; the antigen-MHC molecules may then interact with a T cell receptor.
Major histocompatibility complex. A set of genes found in all mammals whose products are primarily responsible for the rapid rejection of grafts between individuals, and funcion in signalling between lymphocytes and cells presenting antigen.
(Major Histocompatibility Complex, also called HLA in humans) The gene cluster that controls certain aspects of the immune response.
major histocompatibility complex. Part of the genome involved in the immune system's ability to target invading cells and leave one's own cells alone.
Major histocompatibility complex. Cell-membrane receptors that bind to antigens and thus help initiate immune reactions.
major histocompatibility complex. (also called human leukocyte antigens, HLAs) is the mechanism by which the immune system is able to differentiate between self and nonself cells.
Major histocompatibility complex. A group of genes that controls several aspects of the Imo response. MHC genes code for self markers on all body cells.
major histocompatibility complex; molecules expressed on the surface of cells that identify the cell as being "self" vs "foreign". MHC molecules also bind foreign antigens and present them to the immune system. Also known as HLA (human leukocyte antigen) molecules.
Major histocompatibility complex. A cluster of genes on chromosome 6 in humans, encoding cell surface molecules that are polymorphic and that code for antigens which lead to rapid graft rejection between members of a single species which differ at these loci. Several classes of protein such as MHC class I and II proteins are encoded in this region. These in humans, are known as 'Human leukocyte antigens' (HLA).
Major histocompatibility complex. the area on chromosome 6 containing genes that determine the structure of human leukocyte antigen (HLA) molecules
Major histocompatibility complex. Originally recognized as antigens responsible for graft rejection in incompatible hosts after transplantation. These are molecules that bind with processed antigens and are displayed on the surface of cells. MHC class I molecules are displayed on non-immune cells and MHC class II on antigen-presenting cells
MAJOR HISTOCOMPATIBILITY COMPLEX. A group of genes that control aspects of the immune response. The products of these genes, the histocompatibility antigens, are present on every cell of the body and serve as markers to distinguish self from nonself cells. See also Antigen; Histocompatibility Testing.
Major Histocompatibility Complex set of genes coding for proteins involved in antigen presentation.
Major histocompatibility complex. is important in regulating the activity of all immune responses involving T-lymphocytes, as the T-lymphocyte receptor requires the presentation of foreign antigen with a class of MHC molecule. All cells express MHC class I but only a few specialised cells express MHC class II. These latter cells are termed antigen presenting cells and are important in controlling the extent to which an immunological reaction can be mounted. In the CNS, MHC class II expression is low and probably restricted to microglial cells
A genetic region found in all mammals whose products are primarily responsible for the rapid rejection of grafts between individuals, and function in signalling between lymphocytes and cells expressing antigen.