A syndrome characterized by increase body metabolism and muscle rigidity that can result in death. It is triggered in susceptible individuals by commonly used genera anesthetics. More information

Malignant hyperthermia (MH or MHS for "malignant hyperthermia syndrome", or "malignant hyperpyrexia due to anesthesia") is a rare life-threatening condition that is triggered by exposure to drugs used for general anaesthesia, such as volatile anaesthetics or the depolarizing muscle relaxant suxamethonium chloride. In susceptible individuals, these drugs can induce a drastic and uncontrolled increase in skeletal muscle oxidative metabolism which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature, eventually leading to circulatory collapse and death if untreated. MH is often inherited as an autosomal dominant disorder, for which there are at least 6 loci of interest.