Definitions for

**"Lod score"****Related Terms:**Linkage disequilibrium, Genetic distance, Centimorgan, Linkage analysis, Linkage, Genotyping, Genetic analysis, Quantitative trait locus, Genetic polymorphism, Polymorphism, Genetic variability, Random genetic drift, Differential display, Heritability, Genetic fingerprinting, Single nucleotide polymorphism, Genetic drift, Genetic variation, Paternity index, Alignment, Molecular clock, Dna testing, Comparative genomics, Gene frequency, Genetic testing, Sequence analysis, Single nucleotide polymorphisms, Gene testing, Dna fingerprinting, Snp, Inbreeding coefficient, Dna profile, Haplotype, Positional cloning, Ortholog, Genetic linkage, Microarray analysis, Testing, Linked genes, Genetic test, Pooling, Polygene, Reverse genetics, Genetic marker, Synteny, Microarray, Gene pool, Gene mapping, Fingerprinting

Logarithm of the odds favoring linkage obtained from the statistical analysis of linkage. The lod score (Z) of +3 is considered evidence for linkage.

A statistical measure of linkage determined by pedigree analysis.

A measure of the likelihood of two markers being linked. It is calculated as the log of an odds ratio, so higher values indicate stronger linkage.

The logarithm of the odds of linkage between two loci. Calculated from pedigree data, as the log (to base 10) of the ratio of the probability of the observed pedigree assuming linkage with a specified recombination fraction , to the probability of the observed pedigree assuming no linkage, i.e., recombination fraction = 0.5. A lod score (also called a value) is thus calculated as = log10 {Prob(data|)/Prob(data|0.5)}. A lod score of +3.00 (which is odds of 1000:1) or greater is regarded as acceptable evidence for linkage; -2.00 (which is the log of 1:100) or less indicates that no linkage exists.

A statistical estimate of whether two loci are likely to lie near each other on a chromosome and are therefore likely to be inherited together. A LOD score of three or more is generally taken to indicate that the two loci are close.

(Base 10 'logarithm of the odds' or 'log-odds'). A method of hypothesis testing. The logarithm of the ratio between likelihoods under the null and alternative hypotheses.

Logarithm of the odd score; a measure of the likelihood of two loci being within a measurable distance of each other.

a calculation of estimated linkage distance

Statistical test to determine whether a set of linkage data are linked or unlinked. LOD is an abbreviation of `log10 of the odds'. A LOD score of +3 would suggest a 1000:1 chance that there is linkage between a disease trait and a DNA marker in a linkage study.

The logarithm base ten of the likelihood ratio. The name is a contraction of "logarithm of the odds ratio". In linkage analysis this refers to the likelihood that your trait is linked to a particular marker.

An expression of the probability that a gene and a marker are linked.

Log of the odds supporting linkage of two loci. Traditionally, a lod score of 3 or greater is accepted as evidence of linkage between two markers or a marker and a disease gene

a technique for determining the most likely recombination frequency between two loci from pedigree analysis

(Logarithm of the Odds Score) Measure of markers being linked to a particular distance, divided by the odds that they're linked at 50% coinheritance. (50% coinheritance = not linked at all.) LOD of 1 = suggestive, LOD of 2 = probable, LOD of 3 = more than probable, LOD of 4 = proof.

A statistical estimate that measures the probability of two loci being close together and consequently being inherited together. A LOD score of 3 or higher is considered as evidence that two loci lie close together.

Logarithm of the odd score. A statistical estimate of whether two genetic loci are physically near enough to each other (or "linked") on a particular chromosome that they are likely to be inherited together. A LOD score of three or more is generally considered statistically significant evidence of linkage.