Definitions for "Linkage analysis"
Keywords:  heredity, hunting, marker, trace, trait
A gene-hunting technique that traces patterns of heredity in large, high-risk families, in an attempt to locate a disease-causing gene mutation by identifying traits that are co-inherited with it.
A technique in genetic research whereby occurrence of a disorder in a family is evaluated alongside a known genetic marker.
Read chromosomal cross-over first, then come back. Because it can take lots of cross-overs (i.e. lots of generations) to send two genes that live as neighbours on a chromosome into different directions (i.e. they end up in different people), we can do family studies to work out how closely people are related by seeing how long the runs are of identical genes.
A mathematical procedure that uses information from pedigreed populations to determine whether two loci are linked and, if so, how closely.