DNA or RNA that has the complementary sequence of a target DNA / RNA. The term is also used to describe a therapeutic strategy that uses a DNA or RNA sequence that has the reverse orientation of the DNA or RNA sequence of the specific target gene implicated in the disease, in order to bind and inhibit their expression.
a piece of genetic material (DNA or RNA) that binds to a complementary piece of DNA or RNA by base-pairing and prevents that DNA/RNA fragment from being used to produce new viral proteins.
DNA or RNA composed of the complementary sequence to the target DNA/RNA. Also used to describe a therapeutic strategy that uses antisense DNA or RNA sequences to target specific gene DNA sequences or mRNA implicated in disease, in order to bind and physically inhibit their expression by physically blocking them.
The aspect of DNA that is responsible for turning off the function of genes.
the nucleic acid sequence complementary to the sequence that codes for protein. Antisense RNA and DNA have potential therapeutic applications
A piece of DNA producing a mirror image ("antisense") messenger RNA that is opposite in sequence to one directing protein synthesis. Antisense technology is used to selectively turn off production of certain proteins.
An antisense strand of a gene sequence will give rise to mRNA which is complementary to, and therefore will bind to, the product of the sense DNA strand. This prevents the sense transcript from being translated to a gene product.
A strand of DNA that is not responsible for coding. The antisense strand serves as the template for RNA synthesis.
Complementary: an antisense compound is the mirror image of the genetic sequence that it is suppose to inactivate.
Having a sequence complementary to a segment of genetic material and serving to inhibit gene function.
the opposite (miror image) of a genetic sequence, used to inactivate a genetic sequence.
A piece of DNA that produces the mirror image, or antisense messenger RNA, that is exactly opposite in sequence to one that directs the cells to produce a specific protein. Since the antisense RNA binds tightly to its image, it prevents the protein from being made.
In molecular genetics, referring to the strand of a double-stranded DNA that is complementary to the sense strand, the strand of DNA which is used during transcription to make mRNA.
a natural or synthetic DNA or RNA molecule that specifically binds with messenger RNA to selectively inhibit expression of a single gene.
the complementary strand of DNA or RNA coding sequence, which pairs with a specific messenger RNA blocking it from being translated into protein and serving to inhibit gene function.
a piece of nucleic acid, typically created in the lab, which has a sequence exactly opposite to an mRNA molecule made by the body. mRNA molecules made by the body serve as templates for the synthesis of protein (see transcription). Since the "antisense" mRNA molecule binds tightly to its mirror image, it can prevent a particular protein from being made.
A nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it by RNAse H-mediated degradation in the nucleus.
a sequence of DNA that is complementary usually to coding sequence of DNA or mRNA. Has been used experimentally to perturb or block gene expression. Also a mechanism that has been found to occur naturally as a regulatory mechanism.
Way to turn off a gene by putting a "reverse version" or "mirror image" version of the gene into a cell. See marker gene.
Nucleic acid that has a sequence exactly opposite to an mRNA molecule made by the body; binds to the mRNA molecule to prevent a protein from being made. See also: transcription
Antisense molecules interact with complementary strands of nucleic acids, modifying expression of genes.