A cytokine produced by many cell types that causes cytolysis of tumor cells, and mediates the expression of genes involved in the defense against disease.
( TNF) Cytokine produced by monocytes and macrophages in response to LPS (Lecture: Innate Immunity and Inflammation II, 2/21/02)
A chemical substance, which delivers messages between cells in the body, which is involved in inflammation.
A type of biological response modifier (a substance that can improve the body's natural response to disease). Scientists are still learning how this substance causes cancer cells to die.
(TOO-mer neh-KRO-sis FAK-ter) Protein that is produced by the immune system cells monocytes and macrophages in response to endotoxins. TNF activates white blood cells and has antitumor activity.
A natural body protein having anticancer effects
a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)
TOOM-er nek-RO-sis FAC-tor (TNF) An immune system biochemical with varied functions in cancer, infection, and inflammation. 797
TNF alpha and TNF beta; cytokine made by macrophages and some T cells; toxic to tumor cells; plays role in inflammatory responses.
A member of a superfamily of proteins , each with 157 amino acids, which induce necrosis (death) of tumor cells and possess a wide range of proinflammatory actions. Tumor necrosis factor is a multifunctional cytokine with effects on lipid metabolism , coagulation , insulin resistance, and the function of endothelial cells lining blood vessels. See the entire definition of Tumor necrosis factor
a naturally occuring protein, commonly called TNF. TNF destroys cancer cells, but is suspected as being a co-factor in HIV replication.
a cytokine, produced by activated monocytes and macrophages, that can destroy tumors. When chronically elevated (as may occur in HIV disease), TNF-alpha may lead to fever, anorexia, hypermetabolism and wasting. TNF-alpha may block the production of enzymes that digest fats, leading to the breakdown of muscle tissue. In laboratory tests TNF-alpha has been shown to stimulate HIV replication. Some drugs (e.g., thalidomide, ketotifen) reduce TNF-alpha levels. TNF-beta is released by CD4 and CD8 T-cells when stimulated by an antigen. VERIFY TNF-BETA.
(TOO-mer ne-KRO-sis): A type of biological response modifier that can improve the body's natural response to disease.
A protein produced by white blood cells as means of controlling disease and breaking down developing cancer cells, or neoplasms. As a side effect, this defense mechanism can cause inflammation in the body and may trigger conditions such as rheumatoid arthritis.
A type of protein released from cells after exposure to an antigen.
One of the cytokines, or messengers, known to be fundamental to the disease process that underlies psoriasis. It often plays a key role in the onset and the continuation of skin inflammation.
A type of biological response modifier (a substance that can improve the body's natural response to disease). Three types of tumor necrosis factor have been identified: alpha, beta, and gamma. Tumor necrosis factor seems to play a role in the breakdown of cancer cells.
(neck- row-sis): a substance given off by activated white blood cells that can cause the death of tumor cells. See also necrosis.
A macrophage produced cytokine that helps activate T-cells. It is also thought to upregulate HIV replication, and may contribute to the pathogenesis of wasting.
Tumor necrosis factor (TNF, cachexin or cachectin and formally known as tumor necrosis factor alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumourigenesis, and viral replication.
