An eight-base-pair sequence, found about 25 base pairs before the starting point for transcription in many eukaryotic promoters, that binds a transcription factor and thus helps initiate transcription.
A consensus sequence in the 5' region of eukaryotic transcription promoter regions that controls the binding of RNA Polymerase II. The TATA box is also known as the Goldberg-Hogness box.
A sequence found in the promoter (part of the 5' flanking region) of many genes. Deletion of this site (the binding site of transcription factor TFIID) causes a marked reduction in transcription, and gives rise to heterogeneous transcription initiation sites.
A conserved adenine- and thymine-rich promoter sequence located 25-30 bp upstream of a gene, which is the binding site of RNA polymerase. See Pribnow box.
a segment from the startpoint of eukaryotic structural genes to which RNA polymerase binds; the nucleotides most commonly found are TATAAAA
is a conserved A· T-rich septamer found about 25 bp before the startpoint of each eukaryotic RNA polymerase II transcription unit; may be involved in positioning the enzyme for correct initiation.
A TATA box (also called Goldberg-Hogness box)Lifton RP, Goldberg ML, Karp RW, Hogness DS. (1978). The organization of the histone genes in Drosophila melanogaster: functional and evolutionary implications. Cold Spring Harb Symp Quant Biol. 42, 1047-1051.
