Definitions for "Disulfide bond"
A strong covalent bond between two sulfur atoms.
A covalent linkage between two cysteine residues in different parts of a protein or between two different proteins. Insulin (a small protein having two polypeptide chains) and immunoglobulin molecules, for example, have interchain and intrachain disulfide bonds. HLA molecules also have disulfide bonds. The C282Y mutation removes one of the disulfide bonds in the HLA class I-like HFE protein and abolishes its surface expression.
A covalent bond created between sulfur atoms in two molecules of the amino acid cysteine, located at different points in the amino acid chain of a folding protein or peptide. The disulfide bond is often necessary for a protein to fold correctly and be fully functional.