compound made by endothelial cells that cause white blood cells in the blood to “stick” or adhere to one location. Adhesion molecules are part of the innate immune response as theyÂ're released when TNF, IL-IB, interferon and other cytokines, as well as anaphylatoxins from complement, bind to receptors on endothelial cells. Adhesion molecules provide a link from innate immune response activation and atherosclerosis