(ADI) Estimate of the amount of a pesticide in food and drinking water which can be ingested daily over a lifetime by humans without appreciable health risk. It is usually expressed in milligrams per kilogram of body weight. See also Tolerable daily intake. (after Duffus, 1993)
Estimate of the amount of a substance in food or drinking water, expressed on a body mass basis (usually mg/kg body weight), which can be ingested daily over a lifetime by humans without appreciable health risk. For calculation of the daily intake per person, a standard body mass of 60 kg is used. ADI is normally used for food additives (tolerable daily intake is used for contaminants). WHO, 1991 RT tolerable daily intake.
An estimate by the Joint Food and Agricultural Organization (United Nations)/World Health Organization Expert Committee on Food Additives (JECFA) of the amount of a veterinary drug, expressed on a body weight basis, that can be ingested daily over a lifetime without appreciable health risk (standard man=60 kg).
An estimate of the dose resulting from exposure to a toxicant that is likely to be without harmful effect even if continued exposure occurs over a lifetime.
The maximum amount of a substance that can be taken into the body daily over the course of a lifetime without posing a health risk.
The highest daily amount of a substance that may be consumed over a person's lifetime without harmful health effects. Acid Rain: A general term used to describe acid falling to earth in rain, snow, frost, fog or mist. Acid rain is formed when sulfur dioxide and nitrogen oxides released into the air become acid through chemical reactions and then fall to earth.
The maximum dose of a substance that is anticipated to be without health risk to humans when taken daily over the course of a lifetime. ADIs are set by the EPA.
The chemical ingestion level determined by combining the maximum No-Observed-Adverse-Effect-Level (NOAEL) with the addition of an uncertainty (safety) factor. Chemicals with ADI levels usually are not considered or suspected to be carcinogens. This classification results from toxicity data collected during prolonged ingestion studies conducted on a number of animals.
The ADI is based upon the level at which there is no observable toxic effect, as determined in toxicological studies using animal models. An additional safety margin is built into the human ADI by dividing the no-observed-adverse-effect level by a safety factor of 100 or greater. The ADI is a level of dietary exposure that virtually all individuals could consume on a daily basis and even exceed on occasion without experiencing adverse effects.
An estimate of the amount of a substance, expressed on a (ADI) body weight basis, that can be ingested daily over a lifetime without appreciable risk to human health.
A routine approach of FDA and other U.S. and international governmental and nongovernmental organizations to set safe levels of oral intake for chemicals by dividing the no-observed-adverse-effect-level (NOAEL) by safety and uncertainty factors of two to four values of 10 (100 to 10,000).
The amount of chemical that, if ingested daily over a lifetime, appears to be without appreciable effect.
Estimate of the largest amount of chemical to which a person can be exposed on a daily basis that is not anticipated to result in adverse effects (usually expressed in mg/kg/day).
This figure is supposed to specify a maximum average daily level at which people can safely consume an additive for their entire life span. It is expressed in terms of the number of milligrammes of the chemical which may safely be consumed by a human, for each kilogramme of the consumer's body weight, abbreviated to mg/kg bw. This figure is obtained by first identifying in animal tests a daily dosing level at which no adverse effects are observed, and this is called the 'no effect level' (or NEL). The ADI is directly obtained from the NEL simply by dividing it by what is usually termed a 'safety factor' (or SF).
The amount of a chemical a person can be exposed to on a daily basis over an extended period of time (usually a lifetime) without suffering deleterious effects.
The daily intake of a substance which during an entire lifetime appears to be without appreciable risk on the basis of all facts known at the time.
Acceptable Daily Intake or - ADI is a measure of the amount a specific substance (usually a food additive, or a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) over a lifetime without an appreciable health risk. ADIs are expressed by body mass, usually in milligrams (of the substance) per kilograms of body mass per day.
