a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
mutability in life or nature (especially successive alternation from one condition to another)
a change uh circumstances affectin' one's life.
a change of circumstances affectin' one's life.
a change of circumstances affecting one's life.
A change or variation. Detailed description