Definitions for "Suppressor mutation"
A mutation that restores, partially or completely, the loss of function caused by another mutation. Many suppressor mutations are in genes encoding a transfer RNA species; the altered tRNA can recognise the original mutant codon and, during translation, insert an acceptable substitute amino acid into the polypeptide.
A mutation in one gene that reverses the effect of ("suppresses") a mutation in a second gene.
A mutation that reverses the phenotypic effect of a second mutation. Suppressor mutations are frequently used to identify genes encoding interacting proteins.