Drugs that suppress HIV replication by interfering with an HIV enzyme called protease
Drugs that prevent HIV from multiplying by stopping a tool (the protease enzyme) that the virus needs to reproduce itself.
Antiviral drugs that act by inhibiting the virus protease enzyme, thereby preventing viral replication. Specifically, these drugs block the protease enzyme from breaking apart long strands of viral proteins to make the smaller, active HIV proteins that comprise the virion. If the larger HIV proteins are not broken apart, they cannot assemble themselves into new functional HIV particles. FDA has approved the following protease inhibitors as drugs to treat HIV disease: Saquinavir (Invirase, Fortovase), Indinavir (Crixivan), Nelfinavir (Viracept), Ritonavir (Norvir), and Amprenavir (Agenerase).
Proteins that are plentiful in plants. Lab and animal studies show that they may aid DNA repair, which can slow cancer cell division and help return a cell to its normal state. They also may prevent tumors from releasing proteases that destroy neighboring cells. Found especially in soyfoods, also seeds and legumes.
these drugs block the ability of the viral protease to cleave the finished viral polypeptide sequence into the smaller functional enzymes, thus interfering with further production of viruses. This is the newest group of HIV drugs available on the market (saquinavir and ritonavir). Protease inhibitors specific for HCV are under study.
HIV protease is an enzyme that is essential for replication to occur, these drugs inhibit them and thus interfer with the replication of the virus. Back to the Top Q - R
A new class of antiviral drugs that suppress HIV by blocking infected cells from making copies of HIV.
a new class of drugs used to treat HIV infection.
Compounds which inhibit or antagonize biosynthesis or actions of proteases.
HIV protease is an enzyme essential to the replicative life cycle of HIV. The three-dimensional molecular structure of the HIV protease has been fully determined. Pharmaceutical developers therefore are able to rationally design drugs to inhibit the enzyme and thus interfere with replication of the virus. These drugs act by preventing cleavage of HIV viral polyproteins into active proteins; this occurs during the process by which HIV normally replicates. The drugs bind to the enzyme's active site, blocking cleavage of the polyprotein.
A class of antiretroviral drugs, designed to interfere with the action of HIV's protease enzyme. Protease works as "chemical scissors" to cut up newly created chains of protein into smaller pieces. These pieces are then used to build new HIV virus particles. Click here to return to list
Protease inhibitors are drugs that resemble pieces of the protein chain that protease normally cuts. By "gumming up" the protease "scissors," HIV protease inhibitors prevent protease from cutting long chains of proteins and enzymes into shorter pieces that HIV needs to make new copies of itself.5
The second major category of drug used to treat AIDS that works by suppressing the replication of the HIV virus.
type of HIV therapy which works to prevent the spread of the virus.
A substance in the blood that breaks down proteins. Drugs that inhibit protease may stop HIV from breaking down the proteins it needs to grow. Protease inhibitor trials involving PWAs are showing promise and the first drugs are being introduced.
a drug that inhibits HIV protease (an enzyme that breaks down proteins) that is essential to the replicative life cycle of HIV.
Antiviral drugs that act by inhibiting the virus' protease enzyme, thereby preventing viral replication. Specifically, these drugs block the protease enzyme from breaking apart long strands of viral proteins to make the smaller, active HIV proteins that comprise the virion. If the larger HIV proteins are not broken apart, they cannot assemble themselves into new functional HIV particles. HIV protease inhibitors include indinavir, ritonavir, saquinavir, nelfinavir, amprenavir, atazanavir, and fosamprenavir.
A class of antiretroviral drugs, including Atazanavir Sulfate, Amprenavir, Indinavir Sulfate, Saquinavir, Saquinavir Mesylate, Lopinavir/Ritonavir, Ritonavir and Nelfinavir, that bind and block HIV protease from working, thus preventing the production of new infectious viral particules.
Drugs that interfere with the ability of a virus to make copies of itself.
Group of HIV medications that work by inhibiting a viral enzyme known as the protease enzyme, thereby preventing viral replication.
One of the five chemical classes of Anticarcinogens found in soy. Protease inhibitors also protect against the damaging effects of radiation and free radicals, which can attack DNA. Protein A large molecule made up of units called amino acids. Dietary protein is essential for building, repairing, and maintaining body tissues. Soybeans are exceptionally high in quality protein: 35 to 38 percent of the calories in soybeans come from protein. The soybean is the only vegetable offering a complete protein profile. An extensive body of research demonstrates that consuming 25 grams of soy protein per day can lower cholesterol and reduce the risk of heart disease.
