Putative infectious protein that is associated with spongiform encephalopathies such as scrapie, BSE and Creutzfeldt Jakob disease.
An abnormally folded protein that causes disease by inducing normal counterparts within the cell to fold in an abnormal manner and aggregate.
a protein which is able to reproduce. Few known, but they cause disease: scabies
The causal agent of scrapie and other transmissible spongiform encephalopathies, it is a hydrophobic protein containing no nucleic acid.
"An infectious agent made from protein."
a protein that by changing shape (and thus function), induces neighboring proteins to do so too. Research indicates prions can speed up neurogenesis. Malformed prions cause mad cow disease.
proteinaceous infectious particle; linked to scrapie in sheep or Creutzfeldt-Jakob disease in humans.
Protein infectious agent associated with several neurological diseases (scrapie; kuru; Creutzfeld-Jakob syndrome; Alzheimer's disease). Each disease has a different prion.
An unusual infectious agent that consists purely of protein.
An infectious agent proposed to be responsible for Bovine Spongeform Encephalitis (BSE, or "mad cow disease") in cattle, and Jacob-Creutzfeld disease in humans. Prions are controversial because they consist of protein only, and carry no genetic material, making them unique among "living" species.
Infectious particle that is responsible for certain slow-acting diseases such as scrapie in sheep and goats, and Creutzfeldt-Jakob disease in humans. Prions have a protein component, but scientists have not yet detected a nucleic acid component.
(microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system
a constituent protein of brain cells
a form of protein having the normal chemical composition but is shaped differently
a messed up protein type thing that causes diseases by infecting normal proteins
a misfolded protein that is thought to be pathogenic and self replicating
a mutant protein that lacks nucleic acids
a mutated protein in the body that causes other normal proteins to fold abnormally and cause sponge-like holes in the brain
an abnormally shaped form of a normal cellular protein
an abnormal modification of a normal protein found throughout the body and the central nervous system
an aggregate (polymer) of a specific misfolded protein which is normally present in the body
an altered form of a normal brain protein
an infectious agent, lacking either RNA or DNA that attempts to enter into human cells
a nonliving, self - replicating infectious agent made of protein
a normal cellular protein involved in synaptic function at the neuron and coded by a single gene
a proteinaceous infectious agent that behaves as an inheritable trait, although it contains no nucleic acid
a pro teinaceous in fectious particle
a protein comprising a specific sequence of amino acids
a protein, not an organism
a protein that exists in all mammals, including humans
a type of protein and proteins are made of amino acids
a unique particle that contains no nucleic acid and differs from bacteria, viruses, fungi, viroids and plasmids
a very small protein that sits there and converts other proteins into itself
A protein that, when misshapen, can cause other prions to fold wrongly. Causes all TSEs.
A tiny infectious protein particle, smaller than a virus, that entirely lacks genetic material such as DNA. Prions are thought to be the cause of BSE in cows, scrapie in sheep, and the human diseases CJD and kuru.
Prions are infectious agents which (almost certainly) do not have nucleic acid - a protein alone seems to be the infectious agent. Prions are small proteinaceous infectious particles which resist inactivation by procedures that modify nucleic acids. Prion diseases are often called spongiform encephalopathies because of the post-mortem appearance of the brain with large "holes" in the cortex and cerebellum.
a protein particle that lacks nucleic acid and has been implicated as the cause of various neurodegenerative diseases (as scrapie, Creutzfeldt-Jakob disease, and bovine spongiform encephalopathy). It is a pathogenic form of a neural protein that is both less soluble and more resistant to enzyme degradation than the normal form.
A protein particle found in brain cell membranes. Changes in its structure appear to be related to infectious diseases of the nervous system, such as Creutzfeld-Jakob disease in humans, bovine spongiform encephalopathy in cows, and sheep scrapie.
A small proteinaceous infectious particle which resists inactivation by procedures that modify nucleic acid. Most researchers think that prions are the cause of several diseases including scrapie in sheep, bovine spongiform encephalopathy in cattle and kuru and Creutzfeldt-Jakob disease in humans. More information about prions can be found at Prions: Puzzling infectious proteins (National Institutes of Health, USA)
A novel infectious protein that kills when it changes shape within the cell and provokes suicide program. Over time can kill billions of brain cells. Creates a chain reaction by changing shape of normal cellular prion proteins and causing them too to kill cells. Is highly infectious and can cross species, although not all the time.
now widely thought to be the infectious agent of TSEs, they are built up from PrP proteins which are produced naturally in the body, which has been mutated by a TSE. The Prion has been internationally defined as "small proteinaceous infectious particles which resist inactivation by procedures that modify nucleic acids".
An infectious agent thought to be composed solely of protein. Term is derived from "Protein infectious agent".
A prion is a rogue protein, that appears to cause Bovine spongiform encephalopathy (BSE).
a naturally occurring protein that can be converted into a disease-causing form. Prion diseases can be transmitted in the absence of DNA or RNA.
PROteinaceous INfectious agent. The prion theory suggests that the infective agent of CJD (and the other TSEs) is only composed of a protein and does not contain nucleic acid which would be necessary if the agent was a conventional virius.
concentrated animal protein, implicated as an agent in causing spongiform diseases such as CJD and BSE.
Proteinaceous infectious particle that causes degenerative disorders of the central nervous system, such as "scrapie" in sheep and Creutzfeldt-Jacob disease in humans.
normal cell protein present on nerve cell membranes. It is found in most mammals, but its normal function is unclear. Abnormal prions are thought to cause certain diseases including mad cow disease.
An abnormally shaped protein in the central nervous system that causes a family of infectious diseases that affect the brain.
This is the protein that makes up the infectious agent claimed by a large number of groups now to be the infectious particle that transmits the disease from one cell to another and from one animal to another. It is made from the normal protein PrPc (the c stands for chromosomal) that is produced in small quantities on many cells and especially the lymphoid and nervous tissue cells.
is a contraction of the descriptive term, proteinaceous infectious proteins. Prions, unlike viruses, bacteria and fungi, have no DNA and consist only of protein and the infectious form can cause degenerative brain diseases.
an infectious abnormal form of a normal protein that is replicated in the host by forcing normal proteins of the same type to adopt the aberrant structure of the prion. These proteins have the same amino acid sequence but their tertiary structure is different. A nice example of the preminent importance of protein higher structure
An infectious particle compoased of protein, containing no genetic material
A protein molecule that lacks nucleic acid, that is, no DNA or RNA, often considered to be the cause of various infectious diseases of the nervous system (such as Creutzfeldt-Jakob disease and scrapie.) Very resilient, not easy to kill.
A prion (.) — short for proteinaceous infectious particle that lacks nucleic acid (by analogy to virion) — is a type of infectious agent made only of protein. Prions are believed to infect and propagate by refolding abnormally into a structure which is able to convert normal molecules of the protein into the abnormally structured form, and they are generally quite resistant to denaturation by protease, heat, radiation, and formalin treatments, although potency or infectivity can be reduced. The term does not, however, a priori preclude other mechanisms of transmission.