Sir James Douglas (also known as Good Sir James and the Black Douglas), (1286 – August 25, 1330), was a Scottish soldier and knight who fought in the Scottish Wars of Independence. He was a son of Sir William Douglas, the 'Hardy', who had been a supporter of William Wallace (the elder Douglas died in 1298, a prisoner in the Tower of London). His mother was Elizabeth Stewart, the daughter of Alexander Stewart, 4th High Steward of Scotland.

Dr James Douglas (March 21, 1675 - April 2, 1742), was a Scottish physician and anatomist, member of the Royal Society, and physician to the Queen.

Sir James Douglas, K.C.B, (August 15, 1803 – August 2 1877), was a British colonial administrator and executive of the Hudson's Bay Company. From 1851 to 1864, he was governor of the Colony of Vancouver Island. He then became first governor of the mainland Colony of British Columbia in 1858 in order to assert British authority during the Fraser River gold rush, which had the potential to turn the mainland into an American state.