Indications: Treatment of MAC infection in combination with other agents; prophylaxis of MAC infection. Contraindications: Known hypersensitivity to macrolide antibiotics. Dosage: MAC treatment and prophylaxis: 500 mg po bid. Toxicity: Gastrointestinal intolerance, abnormal liver function tests. Pregnancy category C; teratogenic in animals.
Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), skin and skin structure infections, and, in HIV and AIDS patients to prevent, and to treat, disseminated Mycobacterium avium complex or MAC. In addition, it is sometimes used to treat Legionellosis.