A vesicle is a well demarcated elevation of the superficial layers of the skin less than 1 cm in diameter. The skin elevation is due to accumulation of intercellular fluid beneath the roof of the vesicle. The fluid is usually serum or an inflammatory exudate. Vesicles as seen in viral diseases, irritant contact dermatitis and autoimmune disorders are often superficial; therefore the vesicles are often transient, with crusting and erosions common.