Containing substitutions or replacements; having been subjected to the process of substitution, or having some of its parts replaced; as, alcohol is a substituted water; methyl amine is a substituted ammonia.

The creatinine concentration is less than 2 mg/dL and the specific gravity is less than or equal to 1.001 or greater than or equal to 1.020.

Exchanged; put in the place of another.