See Anemia, sickle cell.

a blood disorder passed down from parents to children. It involves problems in the red blood cells. Normal red blood cells are round and smooth and move through blood vessels easily. Sickle cells are hard and have a curved edge. These cells cannot squeeze through small blood vessels. They block the organs from getting blood. Your body destroys sickle red cells quickly, but it can’t make new red blood cells fast enough-- a condition called anemia.

A disease marked by anemia and by ulcers and characterized by the red blood cells of the patient a sickle-like or crescent shape. This disease is hereditary and appears to be confined to the black population.

This is a hereditary and familial form of chronic, hemolytic anemia essentially peculiar to Negroes. It is characterized clinically by symptoms of anemia, joint pains, leg ulcers, acute attacks of abdominal pain and is distinguished hematologically by the presence of distinct hemoglobin, peculiar sickle-shaped and oat-shaped red corpuscles, and signs of excessive blood destruction and active blood formation.

A genetic disease in which the hemoglobin protein is mutated, giving red blood cells a twisted shape that may painfully block circulation. This often leads to medical crises and may cause an early death. The recessive disease occurs in children who have inherited the mutated gene from both their parents, mostly among people of African or Mediterranean origin.

An inherited disorder of red blood cells with severe anemia.

The most common form of sickle cell disease. Other types of sickle cell disease include hemoglobin SC disease and sickle beta-thalassemia; there are also other, less common types of sickle cell disease.

a chronic , incurable condition that causes the body to produce defective hemoglobin , which forces red blood cells to assume an abnormal crescent shape

an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped

an autosomal recessive condition which causes red blood cells to be become malformed in shape or "sickle-shaped" due to abnormal hemoglobin structure.

A chronic anemia inherited from one or both parents that causes the blood cells to assume a sickle shape. Most common among African-Americans.

An inherited disorder of the red blood cells in which the hemoglobin (the red oxygen carrying pigment of the cell) is different from the usual type. This unusual hemoglobin results in the production of unusually shaped cells, which do not survive the usual length of time in the blood circulation. Thus, anemia results. Sickle cell anemia is the result of the inheritance of the gene for sickle hemoglobin (S) from both parents.

most common sickling disease in the United States.

A hereditary form of anemia mainly affecting African Americans. Causes red blood cells to produce abnormal hemoglobin, resulting in abdominal and bone pain and leg ulcerations.

a single base mutation in DNA results in substitution of valine for glutamic acid at the sixth position of the -globin chain of hemoglobin. Circulating sickled erythrocytes are selectively removed by the spleen. About 10 percent of US blacks are heterozygous for the sickle cell gene.

A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S . Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest areas of the body. See the entire definition of Sickle cell anemia

an inherited blood disorder characterized by defective hemoglobin.

Human autosomal recessive disease that causes production of abnormal red blood cells that collapse (or sickle) and cause circulatory problems.

A recessive genetic disorder in which red blood cells take on an unusual shape, leading to other problems with the blood.

an inherited condition where a person's red blood cells are misshapen and less capable of carrying oxygen

An inherited type of anemia which occurs most often in Africans and African Americans. The disease gets its name from the sickle shape (a C-shape) of the red blood cells. These cells cannot move oxygen very well. The disease is sometimes treated with a marrow or blood stem cell transplant.

a hereditary form of anemia in which the red blood cells are abnormally shaped

An inherited blood disease in which the red blood cells contain an abnormal from of hemoglobin, the protein that transports oxygen from the lungs to the rest of the body.

a heritable condition of the hemoglobin whereby the red blood cells take on a sickling shape instead of the characteristic round shape. The sickling shape prevents the red blood cell from carrying oxygen adequately. Sickle cell anemia is most prevalent in African American populations.

A hereditary disease in which a mutation in the gene for one of the proteins that comprises hemoglobin results in the formation of defective hemoglobin molecules known as hemoglobin S. Individuals who are homozygous for this mutation (possess two genes for hemoglobin S) have red blood cells that change from the normal discoid shape to a sickle shape when the oxygen supply is low. These sickle-shaped cells are easily trapped in capillaries and damaged, resulting in severe anemia. Individuals who are heterozygous for the mutation (possess one gene for hemoglobin S and one normal hemoglobin gene) have increased resistance to malaria.

an inherited autosomal recessive condition that causes abnormal hemoglobin in blood cells, leading to infections and organ damage.

Anemia is a qualitative or quantitative reduction in the RBC (red blood cells) of blood. Sickle cell anemia, which is a genetically acquired disease, is a qualitative reduction in the RBC function. It is characterized by the presence of sickle or crescent shaped cells in the blood.. A Pale tongue and eyes, fatigability, lack of usual energy, leg ulcers and arthrotic problems are the main manifestations of this disease.

A genetic disease that primary occurs in people of African descent. Red blood cells change shape and lodge in the capillaries, obstructing blood flow to downstream tissue. This disease usually occurs in painful attacks and can cause serious damage to organs.