Indications: Treatment of MAC infection in combination with other agents; treatment of TB in combination with other agents; prophylaxis of MAC infection in patients unable to tolerate clarithromycin or azithromycin. Contraindications: Known hypersensitivity. Dosage: Treatment and prophylaxis: 300 mg po qd (or 600 mg 2-3 times a week [DOT]). There are many potential drug interactions, some of which require dosage modification; see Physicians Desk Reference or package insert for more information. Toxicity: Orange discoloration of body secretions, gastrointestinal intolerance, abnormal liver function tests. Acute uveitis has been reported when used in association with clarithromycin. Pregnancy category C.

Rifabutin is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependend RNA-polymerase of the bacteria.