The DNA-replicating structure at the replication fork consisting of two DNA polymerase III enzymes and a primosome (primase and DNA helicase).
a complex dynamic system employing a variety of proteins to orchestrate the synthesis of DNA on both the leading and lagging strands
The complete replication apparatus present at a replication fork that carries out the semi-conservative replication of DNA.
is the multiprotein structure that assembles at the bacterial replicating fork to undertake synthesis of DNA. Contains DNA polymerase and other enzymes.
The replication of the DNA of Escherichia coli proceeds via the replisome, a multiprotein workhorse that varies in complexity depending on the organism. The replisome is made up of two DNA polymerase III core enzymes (DNA pol III), which are each made up of three subunits: one with polymerization activity, one with proofreading ability and one that stimulates the proofreading. Mutations to these subunits are often lethal, as replication is an essential function that a cell must carry out before division.
