Definitions for "Receptor tyrosine kinase"
A transmembrane receptor whose cytoplasmic domain includes a tyrosine kinase enzymatic activity. In normal situations, the kinase is activated only on binding of the appropriate ligand to the receptor.
Receptor tyrosine kinases are proteins found in the plasma membrane of the cell. These receptors possess intrinsic tyrosine kinase activity, which is the ability to phosphorylate on a tyrosine residue in a protein. The kinase activity is activated by ligand binding which initiates a signal cascade ultimately leading to alteration in gene expression.
A membrane protein whose extracellular portion binds a neurotrophin. The intracellular portion of the molecule includes a tyrosine protein kinase region, which phosphorylates target proteins when the receptor is occupied.