A copy of a gene that usually lacks introns and other essential DNA sequences necessary for function; pseudogenes, though genetically similar to the original functional gene, are not expressed and often contain numerous mutations Related Terms: deletion ; duplication ; gene conversion ; unequal crossing over
a gene which transcribes a non-functional peptide due to mutation(s). For example, a nuclear pseudogene of mtDNA is a copy of non-functional mtDNA gene incorpotated in the nuclear genome - a possible source of bias when mtDNA analysis is based on PCR with total genomic DNA as a template.
a DNA sequence that bears strong similarity to a functioning gene, but whose protein product is not very likely to be biologically active. Gene families often contain pseudogene members that may have arisen from a f unctional gene during evolution.
Pseudogenes are defunct relatives of known genes that have lost their protein-coding ability or are otherwise no longer expressed in the cell.Vanin, E. F. (1985). "Processed pseudogenes: characteristics and evolution."