any of several types of protein particle lacking nucleic acid, believed to be the cause of certain slow-developing infectious diseases such as scapie in sheep, and Creutzfeldt-Jakob disease and Kuru in humans.
An infectious agent proposed to be responsible for Bovine Spongeform Encephalitis (BSE, or "mad cow disease") in cattle, and Jacob-Creutzfeld disease in humans. Prions are controversial because they consist of protein only, and carry no genetic material, making them unique among "living" species.
Infectious particle that is responsible for certain slow-acting diseases such as scrapie in sheep and goats, and Creutzfeldt-Jakob disease in humans. Prions have a protein component, but scientists have not yet detected a nucleic acid component.
A tiny infectious protein particle, smaller than a virus, that entirely lacks genetic material such as DNA. Prions are thought to be the cause of BSE in cows, scrapie in sheep, and the human diseases CJD and kuru.
Prions are infectious agents which (almost certainly) do not have nucleic acid - a protein alone seems to be the infectious agent. Prions are small proteinaceous infectious particles which resist inactivation by procedures that modify nucleic acids. Prion diseases are often called spongiform encephalopathies because of the post-mortem appearance of the brain with large "holes" in the cortex and cerebellum.
a protein particle that lacks nucleic acid and has been implicated as the cause of various neurodegenerative diseases (as scrapie, Creutzfeldt-Jakob disease, and bovine spongiform encephalopathy). It is a pathogenic form of a neural protein that is both less soluble and more resistant to enzyme degradation than the normal form.
A protein particle found in brain cell membranes. Changes in its structure appear to be related to infectious diseases of the nervous system, such as Creutzfeld-Jakob disease in humans, bovine spongiform encephalopathy in cows, and sheep scrapie.
A small proteinaceous infectious particle which resists inactivation by procedures that modify nucleic acid. Most researchers think that prions are the cause of several diseases including scrapie in sheep, bovine spongiform encephalopathy in cattle and kuru and Creutzfeldt-Jakob disease in humans. More information about prions can be found at Prions: Puzzling infectious proteins (National Institutes of Health, USA)
A novel infectious protein that kills when it changes shape within the cell and provokes suicide program. Over time can kill billions of brain cells. Creates a chain reaction by changing shape of normal cellular prion proteins and causing them too to kill cells. Is highly infectious and can cross species, although not all the time.
now widely thought to be the infectious agent of TSEs, they are built up from PrP proteins which are produced naturally in the body, which has been mutated by a TSE. The Prion has been internationally defined as "small proteinaceous infectious particles which resist inactivation by procedures that modify nucleic acids".
PROteinaceous INfectious agent. The prion theory suggests that the infective agent of CJD (and the other TSEs) is only composed of a protein and does not contain nucleic acid which would be necessary if the agent was a conventional virius.
This is the protein that makes up the infectious agent claimed by a large number of groups now to be the infectious particle that transmits the disease from one cell to another and from one animal to another. It is made from the normal protein PrPc (the c stands for chromosomal) that is produced in small quantities on many cells and especially the lymphoid and nervous tissue cells.
is a contraction of the descriptive term, proteinaceous infectious proteins. Prions, unlike viruses, bacteria and fungi, have no DNA and consist only of protein and the infectious form can cause degenerative brain diseases.
an infectious abnormal form of a normal protein that is replicated in the host by forcing normal proteins of the same type to adopt the aberrant structure of the prion. These proteins have the same amino acid sequence but their tertiary structure is different. A nice example of the preminent importance of protein higher structure
A protein molecule that lacks nucleic acid, that is, no DNA or RNA, often considered to be the cause of various infectious diseases of the nervous system (such as Creutzfeldt-Jakob disease and scrapie.) Very resilient, not easy to kill.
A prion (.) — short for proteinaceous infectious particle that lacks nucleic acid (by analogy to virion) — is a type of infectious agent made only of protein. Prions are believed to infect and propagate by refolding abnormally into a structure which is able to convert normal molecules of the protein into the abnormally structured form, and they are generally quite resistant to denaturation by protease, heat, radiation, and formalin treatments, although potency or infectivity can be reduced. The term does not, however, a priori preclude other mechanisms of transmission.