Synonymous with addiction, the physiological state in which failing to ingest a specific substance leads to bodily symptoms of withdrawal. go to glossary index
A state of adaptation that often includes tolerance and is manifested by a drug classspecific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, decreasing blood levels of the drug, and/or administration of an antagonist.
A condition in which someone develops a tolerance toward a drug or shows withdrawal symptoms without it.
The state of being physiologically dependent on a drug after a prolonged period of use. Withdrawal symptoms occur with abrupt discontinuation of the drug.
Physiologic adaptation of the body to the presence of opioid is required to maintain the same level of analgesia.
An adaptive physiological state that can occur with regular drug use and results in withdrawal when drug use is discontinued.
A condition that may occur after prolonged use of an opiate, but differing from addiction because the user is dependent on the drug for pain relief, rather than emotional or psychological relief.
State in which the use of a drug is required for a person to function normally. Such a state is revealed by withdrawing the drug and noting the occurrence of withdrawal symptoms. This state is relieved in time, or with readministration of the drug.
A condition in which there are withdrawal symptoms if a person suddenly stops using a substance.
Physiological need for a drug that has been brought about by its regular use. Dependence is characterized by withdrawal sickness when administration of the drug is abruptly stopped.
When physical dependence occurs, the body has developed a tolerance for a drug, and larger doses are needed to achieve the same effects the patient experienced when he or she first started taking the medication.
Occurs when a drug is taken over a period of time. Patient may experience sign of withdrawal if stopped abruptly.
A physiological need for a substance, the absence of which leads to withdrawal. Physical dependence is distinguishable from addiction in that addiction also involves mental fixation.
A state of adaptation that is manifested by a specific withdrawal syndrome that can be produced by abrupt cessation of dosing, rapid dose reduction, and/or administration of an antagonist. Most patients on long-term opioid therapy develop physical dependence, which is not predictive of addiction.
When a person cannot function normally without the repeated use of a drug. When the drug is taken away, the person has severe physical and psychic disturbances.
The physical condition in which rapid discontinuation of a substance, such as alcohol, tobacco or a drug, causes a withdrawal reaction.
Changes that the brain and body undergo as they adapt to the continued presence of high doses of drugs. Because of these changes, the brain and body eventually come to require the presence of the drug to work properly.
Chronic opioid use causes the mu-opioid receptors in the brain to become less sensitive (ie, tolerant) to opioid stimulation. This state of adaptation is also manifested by an opioid-specific withdrawal syndrome that can be produced by the abrupt cessation of use/rapid dose reduction, decreasing blood levels of the drug, and/or the adminstration of an opioid agonist. Chronic use of opioids will generally lead to physical dependence in all patients.
An adaptive physiological state that occurs with regular drug use and results in a withdrawal syndrome when drug use is stopped; usually occurs with tolerance.
physical adaptation to chronic use of a specific psychoactive substance. Withdrawal symptoms develop when use ceases, and may be relieved when use is resumed.
A condition in which the presence of a drug or alcohol is required to maintain normal functioning of the central nervous system. (See withdrawal symptoms.) Physical dependence is caused by changes in the relationships among nerve cell membranes, neurotransmitters and their receptors, and the reward pathway.
a physiological state that depends on the continuous presence of a drug; absence of the drug may cause discomfort, nervousness, headaches, and sweating (withdrawal symptoms) and sometimes death
Repeated drug use that causes tolerance.
Physical dependence describes increased tolerance of a drug combined with a physical need of the drug to function. Abrupt cessation of the drug is typically associated with negative physical withdrawal symptoms.Physical addiction appears to occur when repeated use of a drug alters reward pathways in your brain.