A chemical reaction resulting in the addition of phosphate groups to other molecules (e.g., proteins). Phosphorylation reactions often are critical to regulation of receptor activity and the functions of other proteins.
biochemical reaction in which an organic substrate, such as sugar, is combined with a phosphate ion by enzyme reaction. The phosphorylation of some organic substances produce high-energy bonds in the product, for example ATP; these products are highly reactive under enzymatic activation.
Reaction in which a phosphate group become covalently linked to another molecule. The activity of many proteins is regulated by phosphorylation of hydroxyl-containing residues (serine, threonine, tyrosine) by various protein kinases.
The addition of phosphate to an organic compound, such as the addition of phosphate to ADP to form ATP (the function of complex V in the electron transport chain) or the addition of phosphate to glucose to produce glucose monophosphate, through the action of enzymes known as phosphotransferases or kinases.
The addition of a phosphate group to a protein. Phosphorylation occurs in many important processes in the cell. For example, many enzymes are either activated or deactivated by phosphorylation, enabling the cell to control their activity.
A process that modifies the properties of neurons by acting on an ion channel, neurotransmitter receptor or other regulatory molecule. During phosphorylation, a phosphate molecule is placed on another molecule resulting in the activation or inactivation of the receiving molecule. It may lead to a change in the functional activity of the receiving molecule. Phosphorylation is believed to be a necessary step in allowing some neurotransmitters to act and is often the result of second messenger activity.
Phosphorylation is the addition of a phosphate (PO4) group to a protein or a small molecule or "the introduction of a phosphate group into an organic molecule." Its prominent role in biochemistry is the subject of a very large body of research (as of January 2006, the Medline database returns over 120,000 articles on the subject, largely on protein phosphorylation).