The process of flooding fluid through the artery to saturate the surrounding tissue. In regional perfusion, a specific area of the body (usually an arm or a leg) is flooded with high doses of anticancer drugs.
This is the process by which the brain is supplied with blood and therefore oxygen. The process is complicated and not yet fully understood. Where blood pressure falls, or where INTRACRANIAL HYPERTENSION (qv) creates resistance to normal blood flow, perfusion may be impaired. The damaged brain is less good at making normal adjustments in arterial size to 'autoregulate' blood flow, adding a further complication. Obviously, this problem requires skilled neurosurgical management.
chemotherapy technique that may be used when melanoma occurs on an arm or leg. The flow of blood to and from the limb is stopped for a while with a tourniquet, and anticancer drugs are put directly into the blood of the limb. This allows the patient to receive a high dose of drugs in the area where the melanoma occurred.
Perfusion is the passage of fluid through a tissue. It can refer to the passage of blood through the lung tissue to pick up oxygen from the air in the alveoli and the release of carbon dioxide. Or, perfusion can refer to the deliberate introduction of fluid into a tissue, usually by injection into the blood vessels supplying the tissue.
Bathing an organ or tissue with a fluid. In regional perfusion, a specific area of the body (usually an arm or a leg) receives high doses of anticancer drugs through a blood vessel. Such a procedure is performed to treat cancer that has not spread.