Substance that modifies, enhances or diminishes the effect of a neurotransmitter, often via second messengers operating on ion channels; can act presynaptically or postsynaptically.
A compound, released by a neuron, that adjusts the sensitivities of another neuron to specific neurotransmitters.
Compound that is released within a localized region of CNS, the receptor for which is not necessarily sited on an anatomically apposed postsynaptic cell. Thus a neuromodulator may affect several postsynaptic cells with specificity conferred mainly by the distribution of receptors. Main action is on second messenger systems, eg. cAMP or inositole triphosphate, presumably affecting protein phosphorylation, also see Neurohormone, Neurotransmitter
a compound, which has a modulatory effect on neuronal activity, increasing or decreasing the rate at which a nerve cell fires
a chemical that alters the general sensitivity and responsivity of neurones.
A substance released by a neuron that influences other neurons, but is not classified as a neurotransmitter. For example, in C. elegans neuromodulators are thought to influence dauer formation ( Riddle and Albert, 1997) and egg laying ( Schafer, 2006). See Neurotransmitter
A neuromodulator is a substance other than a neurotransmitter, released by a neuron at a synapse and conveying information to adjacent or distant neurons, either enhancing or dampening their activities.