abnormality of the cytoplasm of the pyramidal cells of the hippocampus and cerebral cortex neurons associated with dementias such as Alzheimer's disease.
bundles of twisted filaments found within neurons, and a characteristic feature found in the brains of Alzheimer's patients. These tangles are largely made up of a protein called tau.
collections of twisted tau found in the cell bodies of neurons in AD.
Abnormal bundles of filaments in nerve cells in the brain. These filaments contact on protein tau and are of the typical features of Alzheimer's disease.
Accumulation of twisted protein fragments inside neurons. Neurofibrillary tangles are one of the characteristic structural abnormalities found in the brains of patients with Alzheimer's disease patients. Upon autopsy, the presence of amyloid plaques and neurofibrillary tangles is used to positively diagnose Alzheimer's disease.
collections of twisted nerve cell fibers or paired helical filaments found in the cell bodies of neurons in Alzheimer's disease.
insoluble twisted fibers that are found inside of the brain's cells. They primarily consist of a protein called tau, which forms part of a structure called a microtubule. The microtubule helps transport nutrients and other important substances from one part of the nerve cell to another. When tau protein is changed chemically (phosphorylated tau), it begins to pair with other threads of phosphorylated tau and they become tangled up together. This damages the neuron' ability to communicate and leads to their death.
Intraneuronal structures formed from paired helical filaments, which are composed of abnormally phosphorylated tau proteins, wound together in a double helix.
A fine fiber found in cytoplasm signalling an abnormality of the hippocampus and neurons of the cerebral cortex that occurs especially in Alzheimer's disease.