A component of spinal fluid that is increased in the spinal fluid of some people with MS. The target of autoimmune attack in MS. A component of the myelin sheath targeted by T-cells which release toxic compounds such as TNF (tumor necrosis factor) and gamma interferon.
One of the components of myelin, and of spinal fluid that is increased in the spinal fluid of some, but not all, people with multiple sclerosis.
Proteins associated with the myelin of the central nervous system that may be found in higher than normal concentrations in the cerebrospinal fluid of individuals with MS and other diseases that damage myelin.
One of the principal proteins found in myelin.
a major component of myelin. When myelin breakdown occurs (as in MS), MBP can often be found in abnormally high levels in the patient's cerebrospinal fluid. When injected into laboratory animals, MBP induces experimental allergic encephalomyelitis, a chronic brain and spinal cord disease similar to MS.
A protein, which forms an important part of the myelin sheath. It has proved significant in both inducing and protection again EAE, but this effect has not yet been demonstrated in MS in humans.
Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the central nervous system (CNS).