(see nonsynonymous mutation)
A nonsynonymous mutation, or one that changes a codon for one amino acid to a codon for a different amino acid. (Contrast with frame-shift mutation, nonsense mutation, synonymous mutation.)
Mutations in the nucleotide sequence of DNA can result in the coding of proteins with missense mutations in the amino acids. This can alter the primary amino acid sequence and protein structure of the protein. An example of missense mutations are mutations of the β- myosin heavy chain (MHC) gene that can lead in a number of mutations in the protein that can lead to hypertrophic cardiomyopathy.
A point mutation in which one codon (triplet of bases) is changed into another designating a different amino acid.
An alteration in a nucleotide sequence that converts a codon for one amino acid into a codon for a second amino acid.
Nucleotide substitution that changes one codon for another resulting in a single amino acid change, as in ATG GTG CAC TG ACT to ATG GTG CAC TG GCT, that is, from MetValHis Leu Thr to MetValHis Val Thr. The phenotypic severity of such a mutation depends on the relative functional importance of the amino acid position mutated and on the chemical similarity between the original and the new amino acids.
A mutation that results in the substitution of an amino acid in a protein.
Any mutation that alters a codon so that it codes for a different amino acid.
A mutation that changes a codon for one amino acid to a codon for a different amino acid, resulting in an amino acid substitution in the protein product.
A mutation that alters a codon for a particular amino acid to one specifying a different amino acid.
a single DNA base pair change which results in a different amino acid coded for in a protein
A base pair substitution in a gene which results in one amino acid being changed for another one at a particular place in a polypeptide.
A change in the base sequence of a gene that alters or eliminates a protein.
A base substitution that changes a codon into a codon corresponding to a different amino acid.
A single base pair substitution that results in the translation of a different amino acid at that position
Substitution of a single DNA base that results in a codon that specifies an alternative amino acid.
Base pair change in DNA causing the insertion of a wrong amino acid into a polypeptide chain.
A type of mutation that results in the substitution of one type of amino acid for another in a given location in a polypeptide chain.
A mutation that alters a codon so that it encodes a different amino acid.
mutations that at change a codon for one amino acid into a codon for a different amino acid.
A mutation in which one nucleotide base is substituted for another.
In genetics, missense mutations or nonsynonymous mutations are types of point mutations where a single nucleotide is changed to cause substitution of a different amino acid. This in turn can render the resulting protein nonfunctional. Such mutations are responsible for diseases such as Epidermolysis bullosa and sickle-cell disease.