an analytical method used to identify chemical substances by ionizing the material, focusing the resulting ions into a beam, then separating them according to the ratios of their mass to their net electric charge
A method used to determine the masses of atoms or molecules in which an electrical charge is placed on the molecule and the resulting ions are separated by their mass to charge ratio.
Technique uesed to measure and analyse a substance in terms of the ratios of mass to charge of its components.
The primary proteomic technique used for rapid and very sensitive physical chemical analysis of peptides and proteins, in which molecules first are ionized and then identified by determination of their molecular weight and amino acid sequence.
study of the structure of molecules by using the mass of their basic constituents
Analytical method for measuring molecular mass and structure.
A technique used to identify organic compounds, including proteins, by their mass and electric charge. To utilize mass spectrometry to identify proteins, protein or peptide samples are ionized, or charged, by an ionization source. Two common sources used in proteomics are matrix-assisted laser desorption ionization (MALDI-) and electrospray ionization (ESI-). The ionization source adds protons to the amino acids in the sample. After ionization, the charged protein enters a mass analyzer, such as time-of-flight (TOF-), or quadropole ion flight, which sorts the peptides according to their mass-to-charge ratio. Finally, a detector notes the number of ions over a range of mass-to-charge ratios. The output may produce a "peptide mass fingerprint" - an amino acid sequence or a pattern of unique peptides.
Mass spectrometry is a technique for determining the atomic weight and isotopic abundances of an element or the molecular weight and structure of a compound. Compounds are ionized, fragmented, and passed through a strong magnetic field, which bends their paths by an amount depending on the fragment's charge-to-mass ratio. The fragment ions strike a detector, producing a profile that shows both the relative abundance of the fragments and their masses. The profile (called a mass spectrum) is often used as a characteristic fingerprint for a chemical compound.
A method of chemical analysis which vaporises, then ionises the substance to be analysed and then accelerates the ions through a magnetic field to separate the ions by molecular weight. Mass spectrometry can result in the exact identification of an unknown compound, and is a very powerful analytical technique, especially when combined with chromatography.
An instrumental method used in conjunction with Gas Chromatography that provides accurate information about the molecular mass and structure of complex molecules. This technique can identify and quantify extremely small amounts of drugs or metabolites by their mass-fragment spectrum.
Instrumental method for identifying the chemical constitution of a substance by separating gaseous ions according to their differing mass and charge. In a mass spectrometer, atoms or molecules in a sample are ionized by an electric beam. The ions are accelerated by an electric field and then deflected by a powerful magnet. Different ions are deflected to different degrees, allowing for measurement of abundances of different masses and therefore, isotopic enrichment of a sample.
A technique used to determine the composition and abundance of the atoms in a molecular substance, starting with a very small amount of sample.
Measurement of the mass of atoms or molecules. The molecules are first converted to ions, which are separated using electric or magnetic fields according to the ratio of their mass to electric charge. The measured masses are used to infer the identity of the molecules.
A method of chemical analysis in which a substance is vaporized and exposed to strong electric and magnetic fields to separate and measure its components.
(MS): A method for identifying the chemical constituents of a substance by converting them into gaseous ions, which are then separated and classified according to their mass-to-charge ratios.
The process by which the masses of molecules are measured (in atomic mass units).
An instrument that measures the mass of molecules, used to identify or characterize compounds such as proteins, carbohydrates and nucleic acids.
A method of determining the types, and relative amounts, of ions in a sample. In a mass spectrometer, atoms or molecules in a sample are ionised by an electric beam. The ions are accelerated by an electric field and then deflected by a powerful magnet. Different ions are deflected to different degrees, so the composition of the sample can be determined. More information can be found at Mass spectrometry – Background (Department of Chemistry, University of Illinois, Chicago, USA)
Analytical method that measures the difference in mass-to-charge ratio (m/e) of ionized atoms or molecules to separate them from each other. Mass spectrometry is useful for counting atoms or molecules and also for determining chemical and structural information about molecules (molecules have distinctive fragmentation patterns). In the study of proteins, mass spectrometry data are often combined with liquid chromatography results.
Any of various analytical methods in which atoms are ionized, dispersed, and collected according to mass. Allows the mass of uranium isotopes in a sample to be measured. In this study, the ionizing source was inductively coupled plasma (ICP), hence the acronym ICP-MS.
This is a method of identifying the chemical constitution of a substance by means of the separation of gaseous ions according to their differing mass and charge - called also mass spectroscopy.[27
Technique for obtaining mass spectrum of material. Mass spectrum can be used to determine chemical structure and identify materials.
An instrument used to identify chemicals in a substance by their mass and charge.
a method that uses a sophisticated instrument to identify chemicals in a substance by weighing molecules.
Analytical method for determination of the exact mass, or weight, of a molecule. Mass spectrometry has been used in physics and chemistry for over fifty years. Over the past fifteen years, mass spectrometry has emerged as a powerful research tool in the life sciences, which is mainly due to the development of the new, "soft" ionization techniques ESI and MALDI. Determines directly the identity, amount and structure of small molecules (like drug candidates and metabolites), as well as of large biomolecules (like proteins and DNA).
Any technique which measures the mass of an ion in a vacuum. This is, in essence, a very accurate and sensitive method to weigh a molecule.
A chemical technique used to investigate aspects of the structure of molecules.
apparatus that converts molecules into ions and then separates the ions according to their mass-to-charge ratio. Mass spectrometers are used to identify atoms and isotopes, and determine the chemical composition of a sample.
a form of spectrometry in which, generally, high energy electrons are bombarded onto a sample and this generates charged fragments of the parent substance; these ions are then focused by electrostatic and magnetic fields to give a spectrum of the charged fragments.
This technique can be used to both measure and analyze molecules under study. It involves introducing enough energy into a target molecule to cause its ionization and disintegration. The resulting fragments are then analyzed, based on the mass/ charge ratio to produce a "molecular fingerprint."
a technique for determining the composition of a molecule and its fragments.
A method for identifying molecules based on their mass-to-charge ratio of the ions generated from the molecule by vaporization and electron bombardment.
A chromatographic analysis tool in which sample components are ionized and resolved on the basis of their mass to charge (m/z) ratio due to their behavior in electric and magnetic fields. At one time, instruments used in this technique were cost prohibitive, but new technology and advances in the technique are constantly reducing the cost (and size) of equipment used for this analysis. Currently, mass spectrometry is often coupled with other separation techniques, like gas and liquid chromatography systems, to serve as a detection source.
Mass spectrometry is an analytical tool used for measuring the molecular mass of a sample.
A method for the analysis of the structure of molecules. The analyte is processed to high purity with HPLC and gas chromatography before being passed through as electron beam and the molecular weight of the fragments is determined. It is important that none of the steps add particulate or extractables.
Technique for the detection of chemicals by ionization, followed by the use of a magnetic or electric field to separate the ions according to their mass-to-charge ratio. The ionization can be achieved by bombardment with a stream of electrons from a heated filament ( electron impact) or by the transfer of charge from a prepared ion to the species of interest (chemical ionization). Highly sensitive mass spectrometers have been used to measure small differences in the ratio of isotopes in certain molecules to ascertain, for example, the age of the sample or to assess the nature of the source of the sample.
Mass spectrometry (also known as mass spectroscopy ()Murray, K. K., et al., http://www.iupac.org/reports/provisional/abstract06/murray_prs.pdf Standard Definition of Terms relating to Mass Spectrometry (Provisional) IUPAC Analytical Chemistry Division (2006). or in common speech "mass-spec") is an analytical technique used to measure the mass-to-charge ratio of ions. It is most generally used to find the composition of a physical sample by generating a mass spectrum representing the masses of sample components.