A gene-hunting technique that traces patterns of heredity in large, high-risk families, in an attempt to locate a disease-causing gene mutation by identifying traits that are co-inherited with it.
A technique in genetic research whereby occurrence of a disorder in a family is evaluated alongside a known genetic marker.
Read chromosomal cross-over first, then come back. Because it can take lots of cross-overs (i.e. lots of generations) to send two genes that live as neighbours on a chromosome into different directions (i.e. they end up in different people), we can do family studies to work out how closely people are related by seeing how long the runs are of identical genes.
A genetic technique used to track the inheritance of a genetic condition through a family, using genetic markers closely linked to the suspected disease gene. Requires DNA samples and clinical information from several family members.
Study aimed at establishing linkage between genes.
Tests which are performed on various family members to establish which is the most important information of genetic code for a particular disease.
A gene-hunting technique that attempts to locate a gene by identifying and tracing other traits that tend to be co-inherited with it.
The comparison of two groups of subjects (e.g., people with and without a given disease) to evaluate association between an allele and a phenotype (e.g., a disease).
A statistical technique to identify markers which trace patterns of heredity (genes) in families with several people affected with the disease.
(synonym: indirect DNA analysis) Testing DNA sequence polymorphisms (normal variants) that are near or within a gene of interest to track within a family the inheritance of a disease-causing mutation in a given gene Related Terms: direct DNA analysis ; haplotype analysis ; polymorphism ; recombination
A gene-hunting technique that traces patterns of heredity in large, high-risk families. Linkage analysis attempts to locate a disease-causing gene mutation by identifying genetic markers that are located close to the gene of interest and therefore co-inherited with it.
Genes are said to be "linked" when they reside close together on the same chromosome. Statistical analysis of linkage of two genes is then expressed as a Lod score.
A gene hunting technique that traces patterns of disease in high-risk families, in an attempt to locate a disease-causing gene by identifying genetic markers of known chromosomal location that are co-inherited with the trait of interest.
The process used to study genotype variations between affected and healthy individuals wherein specific regions of the genome that may be inherited with, or "linked" to, disease are determined.