(LOD) quantitative detection limit; limit of determination. The smallest detectable concentration an analytical instrument can determine at a given confidence level. IUPAC defines the quantitative detection limit as Cld = ks/m, where k is 10, s is the standard deviation of instrument readings taken on a "blank" (a solution with zero concentration of analyte), and m is the slope of a plot of instrument response vs. concentration, as calculated by linear regression.

The level above which a quantifiable concentration can be measured in a sample with a specific degree of confidence.

"Quantitation limit is the lowest concentration of analyte in a sample that can be determined with acceptable precision and accuracy under the stated experimental conditions".

The lowest concentration of an analyte that can be determined quantitatively (at acceptable precision) in a particular sample. Exact definitions vary.

Lowest concentration of a pesticide residue in a defined matrix where positive identification and quantitative measurement can be achieved using a specified method. The term limit of quantitation is preferred to limit of determination to differentiate it from LOD. LOQ has been defined as 3 times the LOD (Keith, 1991) or as 50% above the lowest fortification level used to validate the method (US-EPA, 1986).

Lowest level of a material that can be quantitated by technique - typically signal is ten times baseline noise.

the lowest concentration of a chemical that can be accurately and reproducibly quantitated. [Source: Risk Assessment Guidance for Superfund: Volume I -- Human Health Evaluation Manual ( Part A). Interim Final. U.S. Environmental Protection Agency. Office of Emergency and Remedial Response. EPA/540/1-89/002, Types and Definitions of Detection Limits and Quantitation Limits