Isabelle is a Belgian comic book series drawn by Will and with a story by Franquin, Delporte and Macherot.

ISABELLE was a 200+200 GeV proton-proton colliding beam particle accelerator partially built by the United States government at Brookhaven National Laboratory in Upton, New York, before it was cancelled in July, 1983.

Isabelle is an independent 3D adventure game for Microsoft Windows, produced by the French company Belisa in 1997.