a variety of naturally occurring proteins that play a major role in the body's blood-forming and immune systems. Interleukin lymphokines secreted by T-cells including -interferon and interleukin 1, interleukin 2 which are being tested as immunotherapeutic agents. Interleukin 1 produced by macrophages activates helper T cells inducing them to produce interleukin 2. Interleukin 3 stimulates the production of blood cells in the bone marrow.
A group of natural, hormone-like substances that are made in the body by lymphocytes, a type of white blood cell. Interleukins may increase the activity of cells in the immune system that normally recognize and destroy cancer cells.
(in-ter-LOO-kins) -- Biological response modifiers (substances that can improve the body's natural response to disease) that help the immune system fight infection and cancer. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
substances produced (not exclusively) by white blood cells and that play a role in the immune response
naturally occurring chemical "mediators" that influence the inflammatory and immune response by regulating the growth and other activities of other cells.
One of a large group of glycoproteins that act as cytokines. The interleukins are secreted by and affect many different cells in the immune system. See Biotechnology; B Lymphocytes; Genetic Engineering; Killer T Cells; Natural Killer Cells (NK); Lymphocyte; T Cells.
Peptides, released by activated monocytes and lymphocytes, that assist in the coordination of cell-mediated and antibody-mediated immunities.
Cytokines needed for initiation & coordination of immune defense responses
Regulatory proteins, produced by macrophages and lymphocytes, that act upon other lymphocytes and direct their development.
Multifunctional cytokines synthesized by lymphocytes, monocytes, macrophages, and other cells. Cytokines are small, hormonelike molecules that regulate the intensity and duration of the immune response and mediate cell-to-cell communication. Once the structure of a cytokine is determined, it is renamed interleukin.
Proteins that carry regulatory signals between blood-forming cells. Large quantities of interleukins can be produced in the laboratory and used to treat some forms of cancer. Interleukins are biological response modifiers.
Cytokines of the immune system.
are molecules mainly made by leucocytes, and which mostly act on leucocytes. The main targets for interleukin action vary from T and B cells to fibroblasts and endothelium.
A group of molecules involved in signalling between cells of the immune system.
A major group of cytokines.
A variety of naturally occurring polypeptides that are members of the family of cytokines, which affect functions of specific cell types and are found in small quantities. There are twelve identified to date.
A group of cytokines produced mainly by T cells that direct other cells to divide and proliferate.
Substances secreted by lymphocytes: their levels vary with age.
A type of biological response modifier (a substance that can improve the body's natural response to disease). They stimulate the growth of certain disease-fighting blood cells in the immune system.
A group of cytokine-related proteins secreted by leukocytes and involved in the inflammatory immune response of the ischemic cascade.
Cytokines produced by monocytes and macrophages.
A group of about 30 related cytokines that have specific effects on immune cells named Interleukin-1(or IL-1), etc.
A family of substances produced naturally in the body in response to infections and that help the immune system produce more infection- and cancer-fighting cells.
A family of cytokines (chemical messengers) that include IL-1, IL-d (sometimes called T-cell growth factor), IL-10 and IL-12. Different interleukons have different functions: IL-3 promotes the growth and differentiation of several types of blood cells (red, white, and platelets) IL-4 is released by a subset of CD4 cells, and helps stimulate antibody production. IL-6 is produced by macrophages and mediates acute systemic immune responses (e.g., fever). IL-10 stimulates B-cells (which produce antibodies), modulates macrophage function, enhances humoral macrophage function, and enhances humoral immunity, while suppressing cell-mediated immune function. IL-12 is produced by various immune cells, activates natural killer cells and cytotoxic T-lymphocytes and induces the production of interferon-gamma. IL-12 is associated with the cell-mediated immune response. Source: http://www.thebody.com/wa/fall_winter00/interleu.html
Substances (cytokines) that are released from immune and other cells. There are many types referred to as Interleukin (IL) 1, 2, 3, 4, 5, etc.
A series of local chemical signals involved in the immune system and that activate the production of cytotoxic T cells and promote the increased production of helper T cells.
(in-ter- loo-kins): See cytokine
Special proteins released by the immune system to fight bacteria, viruses, and other foreign substances.