Definitions for "Hemoglobinopathies"
Detectable at birth, newborns are screened for hemoglobin diseases which are a group of autosomal recessive disorders characterized by synthesis of abnormal hemoglobin molecules or decreased synthesis of a beta globin chain. Substitution, addition or deletion of amino acids occurs to globin chains. Affected newborns with sickle cell disease may have early overwhelmng sepsis and require prompt evaluation at a comprehensive care facility. Early care and prophylactic penicillin can reduce morbidity and mortality. Prevalence (1:4000 of African descent and 1:1300 in general population.
A group of inherited disorders affecting red blood cells that can result in severe anemia and often other problems. Treatment may involve blood transfusions. Examples are sickle cell disease and thalassemia.
Keywords:  verapamil