This is the tissue type contributed by either the mother or father to their offspring. It is implied that it represents the genes on one set of parental chromosomes. When a transplant procedure is between a donor and recipient who are haplotype identical, it means that the tissue type or HLA type of each is identical in respect to mother or father but not identical to the other. In some situations, if the discrepancy is not too great the transplant may still be possible if the underlying disease makes the risk of partial compatibility warranted. Conditioning of the recipient and lymphocyte depletion of the donor stem cell suspension are steps taken to mitigate the risk of immune cell activation by the tissue type differences.
Genotype of genetically linked loci that are inherited in a block as a single unit. Your Y-DNA haplotype is a set numbers, each number representing your allele at a given STR marker. Two or more haplotypes may be compared as a check for a genetic relationship.
Set of allelic states found at neighbouring loci in a chromosome, as inherited from a parent. Haplotypes can be broken down by recombination. A haplotype shared among unrelated individuals affected with a genetic disease may indicate that a gene causing the disease maps to that genomic region.
the results of the Y DNA test, the markers and their scores [allele values], are called a haplotype. When two or more results are a close match, the haplotype indicates sharing of a common ancestor. The haplotype, is also sometimes referred to as a fingerprint, blueprint, signature, pattern. The numbers are also known as "allele values" and sometimes are referred to as STR numbers.
Broadly, the complete set of results obtained from multiple markers located on a single chromosome. For the Y chromosome, the term is restricted by convention to allele values (number of repeats) obtained from microsatellite (STR) markers, as described by the Y Chromosome Consortium (YCC).
a stretch of DNA where the SNPs are correlated with each other, and that is a project that's now underway and is going to have in the next roughly two years the ability to produce this gold standard set of SNPs
A set of signature genetic changes (polymorphisms) that are normally grouped closely together on the DNA strand. This set of changes is usually inherited as a group and is referred to as a haplotype (Ford, 1997).
Pertaining to a particular set of alleles at linked loci (or nucleotide changes within a gene) that are found together on a single homolog. In linkage studies with backcross offspring and RI strains, the haplotypes associated with each sample provide a means for determining the order of loci (see Chapter 9). See Haplotype in the MGI Glossary.
The alleles found on a single chromosome present at the known polymorphic sites in a gene or region of genomic DNA. The two haplotypes of a gene carried by an individual are that individual's alleles for the gene. HAP(tm) Marker A derivation of the technical term haplotype, which at the molecular level, is a combination of nucleotides that are present at each of the polymorphic sites on a chromosome in selected regions of a gene. These selected regions include the region immediately upstream of the first coding exon (the promoter); the protein coding regions (exons); the intron/exon boundaries; and the last exon through at least the termination codon. A HAP(tm) Marker is discovered electronically using proprietary algorithms based on well-established genetic principles. HAP(tm) Technology The combination of our HAP® Database, our DecoGen Informatics System, our HAP(tm) Typing Facility and our clinical genetics expertise. HAP(tm) Typing HAP(tm) Typing describes the process of determining which HAP(tm) Marker is present for each of the two versions of a gene in a patient's clinical sample.
The particular combination of alleles present within a defined region of some chromosome. Originally was coined to describe MHC antigens, but now is used to describe RFLP patterns and certain other situations.
A specific combination of single nucleotide polymorphisms (SNPs) associated with a particular gene used to measure genetic variability. Haplotypes are a convenient way to organise genetic variation and particular haplotypes can be correlated with drug response.
One of the alternative forms of the genotype of a set of genes that are inherited as a unit. This term is applied to gene complexes rather than the term allele, which refers to one of the forms of a single gene.
Closely linked alleles along a region of a chromosome which tend to be inherited together. A haplotype is identified by patterns of SNPs. Haplotype maps are intended to identify complex genetic variations of importance to health and disease.
A set of closely linked alleles (genes or DNA polymorphisms) inherited as a unit. The line of data in the charts of this website for each participant constitutes the haplotype for that person. Haplotypes can be grouped together to suggest a common distant ancestor.
Conventionally used to refer to the particular alleles present at the four genes of the HLA complex on chromosome 6. The term is also used to describe DNA sequence variants on a particular chromosome adjacent to or closely flanking a locus of interest.
A haplotype is the genetic constitution of an individual chromosome. Haplotype may refer to only one locus or to an entire genome. In the case of diploid organisms such as humans, a genome-wide haplotype comprises one member of the pair of alleles for each locus (that is, half of a diploid genome).