Glucuronidases are glycoside hydrolases that cleave glucuronic acid glycosides (glucuronides). Human glucuronidase is a lysosomal glycosidase, and hydrolyzes glucuronide moieties from proteins. Glucuronidase exhibits both endo-glycosidase and exo-glycosidase activities, meaning that it can cleave monosaccharides from the middle of a chain or from the end.